5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Sleep problems are widely prevalent and associated with various comorbidities including
anxiety. Valerian (Valeriana officinalis L.) is a popular herbal medicine used as a sleep aid …

Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

Serotonin, 5-hydroxytryptamine (5-HT), is one of the class of monoamine neurontransmitters,
all of which have a chemical template comprised of a basic amino group separated from an …

Symptoms of cognitive dysfunction like memory loss, poor concentration, impaired learning
and executive functions are characteristic features of both schizophrenia and Alzheimer's …

Serotonin regulates many physiological processes including sleep, appetite, and mood.
Thus, serotonergic system is an important target in the treatment of psychiatric disorders …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

The primary mammalian circadian clock resides in the suprachiasmatic nucleus (SCN), a
recipient of dense retinohypothalamic innervation. In its most basic form, the circadian …

Serotonin is an ancient molecular signal and a recognized neurotransmitter brainwide
distributed with particular presence in hippocampus. Almost all serotonin receptor subtypes …