Serotonin is an ancient molecular signal and a recognized neurotransmitter brainwide
distributed with particular presence in hippocampus. Almost all serotonin receptor subtypes …

Evidence suggesting that central nervous system γ-aminobutyric acid (GABA)
concentrations are reduced in patients with major depressive disorder (MDD) has been …

Although the cardinal manifestations of Parkinson's disease (PD) are attributed to a decline
in dopamine levels in the striatum, a breadth of non-motor features and treatment-related …

Background Irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal
tract characterized by abdominal discomfort, pain and changes in bowel habits, often …

Insomnia is the most frequently encountered sleep complaint worldwide. While many
prescription drugs are used to treat insomnia, extracts of valerian (Valeriana officinalis L …

Abstract Serotonin (5-hydroxytrympamine or 5-HT) is one of the phylogenetically oldest
neurotransmitters, and the serotonergic system is among the earliest developed neuronal …

Following the cloning of the 5-HT7 receptor in 1993, studies to investigate 5-HT7 receptor
function in native tissues focused on identifying functional correlates that matched the …

Disruption of the microbiota–gut–brain axis results in a wide range of pathologies that are
affected, from the brain to the intestine. Gut hormones released by enteroendocrine cells to …

It has been known for several decades that serotonergic neurotransmission is a key
regulator of cognitive function, mood, and sleep. Yet with the relatively recent discoveries of …

Several recent studies have emphasized a crucial role for the interactions between
serotonergic and dopaminergic systems in movement control and the pathophysiology of …