The optimisation of molecular properties within a series of 2-amino dihydroquinazoline 5-
HT5A/5-HT7 receptor ligands resulted in a significantly improved brain-to-plasma ratio …

It is known that serotonin exerts its different nociceptive and motor functions by interacting
with distinct receptors subtypes, which could be either G-protein coupled or ionotropic …

Although the 5-HT5 receptor subfamily was discovered more than 15 years ago, it is
unambiguously the least known 5-HT receptor subtype. The Gi/G0-mediated signal …

Life of terrestrial vertebrates depends on the maintenance of water and salt in the
extracellular compartment (“internal milieu”) within strictly regulated boundaries …

Effective antidepressants include monoamine oxidase inhibitors and tricyclic
antidepressants, selective serotonin re-uptake inhibitors and novel agents, including …

Neural stem cells reside in the subventricular zone and the dentate gyrus of the
hippocampus in adult mammalian brain. In the hippocampus, a number of factors are …

Mammalian circadian activity rhythms are generated by pacemaker cells in the
suprachiasmatic nucleus (SCN). As revealed by the actions of diverse agonists, serotonergic …

ERp29 is a recently discovered resident of the endoplasmic reticulum (ER) that is abundant
in brain and most other mammalian tissues. Investigations of nonneural secretory tissues …

Serotonergic modulation of circadian rhythms in rodent model preparations has received
considerable attention over the past decade. Investigators have also been trying to …

5-Hydroxytryptamine (5-HT) is involved in a variety of different physiological processes and
behaviors through the activation of equally diverse receptors subtypes. In this work we …