Over the past years, several lines of evidence support a therapeutic potential of Cannabis
derivatives and in particular phytocannabinoids. Δ 9-THC and cannabidiol (CBD) are the …

Background Comprehensive literature reviews of historical perspectives and evidence
supporting cannabis/cannabinoids in the treatment of pain, including migraine and …

Background Synthetic cannabinoids (SC) are a heterogeneous group of compounds
developed to probe the endogenous cannabinoid system or as potential therapeutics …

The endocannabinoid system (ECS) is composed of two G protein-coupled receptors
(GPCRs), the cannabinoid CB1 and CB2 receptors, and the two main endogenous lipid …

Cannabis is a complex plant, with major compounds such as delta-9-tetrahydrocannabinol
and cannabidiol, which have opposing effects. The discovery of its compounds has led to …

Isolation and structure elucidation of most of the major cannabinoid constituents—including
Δ9-tetrahydrocannabinol (Δ9-THC), which is the principal psychoactive molecule in …

Background Medicinal cannabis registries typically report pain as the most common reason
for use. It would be clinically useful to identify patterns of cannabis treatment in migraine and …

The continuous crosstalk between microglia and neurons is required for microglia
housekeeping functions and contributes to brain homeostasis. Through these exchanges …

Background The use of cannabis, or marijuana, for medicinal purposes is deeply rooted
though history, dating back to ancient times. It once held a prominent position in the history …

An agonist that acts through a single receptor can activate numerous signaling pathways.
Recent studies have suggested that different ligands can differentially activate these …