Wilson disease is an inherited autosomal recessive disorder of hepatic copper metabolism
leading to copper accumulation in hepatocytes and in extrahepatic organs such as the brain …

The widespread availability and frequent use of serum chemistry tests have resulted in a
dramatic increase in the number of normal and abnormal liver chemistry test values that …

Copper is an essential metal required for many metalloproteins' function. A fraction of dietary
copper (average 2–5 mg/day) is absorbed by enterocytes in the duodenum and proximal …

This Clinical Practice Guideline (CPG) has been developed to assist physicians and other
healthcare providers in the diagnosis and management of patients with Wilson's disease …

Copper is an essential metal that is an important cofactor for many proteins. The average
diet provides substantial amounts of copper, typically 2-5 mg/day; the recommended intake …

Metabolic processes utilize a variety of differing and contrasting biochemical routes to
enable synthesis of degradation and activation or deactivation of substances; in addition …

This guideline is intended for use by physicians. It describes preferable up-to-date
approaches to the diagnosis and treatment of patients with Wilson disease. As their purpose …

Clinical practice guidelines for Wilson's disease (WD) have been published by the American
Association for the Study of Liver Diseases and European Association for the Study of the …

Background & Aims Alpha-1 antitrypsin deficiency (AATD) is an uncommonly recognized
cause of liver disease in adults, with descriptions of its natural history limited to case series …

Background & Aims: A 5-fold increase of hepatic copper concentration is considered as the
best available test for diagnosis of hepatic Wilson's disease (WD). However, the sensitivity …