[HTML][HTML] 新型DNA 碱基编辑器的研究进展
张雅玲， 王锌和， 李构思， 曾栋昌， 祝钦泷… - 华南农业大学 …, 2022 - xuebao.scau.edu.cn
DNA 碱基编辑技术是由CRISPR/Cas 系统发展而来, 能对基因组碱基进行精准编辑.
目前已开发的DNA 碱基编辑器包括介导C• G 至T• A 转换的胞嘧啶单碱基编辑器, 介导A• T 至G• …
目前已开发的DNA 碱基编辑器包括介导C• G 至T• A 转换的胞嘧啶单碱基编辑器, 介导A• T 至G• …
Expanding plant genome editing scope and profiles with CRISPR‐FrCas9 systems targeting palindromic TA sites
CRISPR‐Cas9 is widely used for genome editing, but its PAM sequence requirements limit
its efficiency. In this study, we explore Faecalibaculum rodentium Cas9 (FrCas9) for plant …
its efficiency. In this study, we explore Faecalibaculum rodentium Cas9 (FrCas9) for plant …
PhieDBEs: a DBD‐containing, PAM‐flexible, high‐efficiency dual base editor toolbox with wide targeting scope for use in plants
Z Zheng, T Liu, N Chai, D Zeng, R Zhang… - Plant Biotechnology …, 2024 - Wiley Online Library
Dual base editors (DBEs) enable simultaneous A‐to‐G and C‐to‐T conversions, expanding
mutation types. However, low editing efficiency and narrow targeting range limit the …
mutation types. However, low editing efficiency and narrow targeting range limit the …
T-LOC: a comprehensive tool to localize and characterize T-DNA integration sites
S Li, C Wang, C You, X Zhou, H Zhou - Plant Physiology, 2022 - academic.oup.com
Scientists have developed many approaches based on PCR or next-generation sequencing
to localize and characterize integrated T-DNAs in transgenic plants generated by …
to localize and characterize integrated T-DNAs in transgenic plants generated by …
[HTML][HTML] CRISPR/Cas genome editing in soybean: Challenges and new insights to overcome existing bottlenecks
NS Freitas-Alves, CE Moreira-Pinto… - Journal of Advanced …, 2024 - Elsevier
Background Soybean is a worldwide-cultivated crop due to its applications in the food, feed,
and biodiesel industries. Genome editing in soybean began with ZFN and TALEN …
and biodiesel industries. Genome editing in soybean began with ZFN and TALEN …
Engineering precise adenine base editor with infinitesimal rates of bystander mutations and off-target editing
L Chen, S Zhang, N Xue, M Hong, X Zhang, D Zhang… - bioRxiv, 2022 - biorxiv.org
Adenine base editors (ABEs) catalyze A-to-G transitions showing broad applications, but
their bystander mutations and off-target editing effects raise the concerns of safety issues …
their bystander mutations and off-target editing effects raise the concerns of safety issues …
[PDF][PDF] Saisine du Comité Scientifique CTPS
L Jolly, A Gouleau, B Bakan, V Bertoux, S Cordeau… - 2022 - geves.fr
Le CTPS, Comité Technique Permanent de la Sélection des Plantes Cultivées, est une
commission administrative à caractère consultatif assurant une mission de conseil et d'appui …
commission administrative à caractère consultatif assurant une mission de conseil et d'appui …
Safety of genome editing: development of a fluorescent model system to investigate reducing off-target genome edits by base editors
T Morin - 2022 - open.library.ubc.ca
Gene editing is a potential treatment for genetic diseases, but current gene editing
technologies are limited in their use and safety. CRISPR-Cas9 installs double stranded …
technologies are limited in their use and safety. CRISPR-Cas9 installs double stranded …