Background Cerebral small vessel disease, a common cause of vascular dementia, is often
considered clinically silent before dementia or stroke become apparent. However, some …

Introduction The primary aim of this paper is to improve the clinical interpretation of white
matter hyperintensities (WMHs) and provide an overarching summary of methodological …

Objective: Mild behavioral impairment (MBI) is characterized as later-life–emergent and
persistent neuropsychiatric symptoms (NPS). The symptom persistence criterion of MBI has …

Age-associated cerebral small vessel disease (CSVD) represents a clinically heterogenous
condition, arising from diverse microvascular mechanisms. These lead to chronic …

We performed a systematic review and meta-analysis on prospective studies that provided
risk estimates for the impact of 3 different MRI markers of small vessel disease (SVD) …

Background Neuropsychiatric symptoms could form part of an early cerebral small vessel
disease prodrome that is detectable before stroke or dementia onset. We aimed to identify …

Dementia is a multifactorial disorder that is likely influenced by both Alzheimer's disease
(AD) and vascular pathologies. We evaluated domain-specific cognitive and …

Background Neuropsychiatric symptoms associate cross-sectionally with cerebral small
vessel disease but it is not clear whether these symptoms could act as early clinical markers …

Background: The links between cerebral small vessel disease (CSVD) burden and
neuropsychiatric symptoms (NPS) have not been fully studied. Objective: We aimed to …

Background Cortical cerebral microinfarcts are a small vessel disease biomarker underlying
cognitive impairment and dementia. However, it is unknown whether cortical cerebral …