Nano-based drug delivery of polyphenolic compounds for cancer treatment: Progress, opportunities, and challenges
W Jia, L Zhou, L Li, P Zhou, Z Shen - Pharmaceuticals, 2023 - mdpi.com
Polyphenols and their derivates, a kind of natural product distributed in herb plants,
vegetables, and fruits, are the most abundant antioxidants in the human diet and have been …
vegetables, and fruits, are the most abundant antioxidants in the human diet and have been …
[HTML][HTML] Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system?
P Tang, T Shen, H Wang, R Zhang, X Zhang… - Biomedicine & …, 2023 - Elsevier
Bioactive natural products (BNPs) are the marrow of medicinal plants, which are the
secondary metabolites of organisms and have been the most famous drug discovery …
secondary metabolites of organisms and have been the most famous drug discovery …
Dirigent gene editing of gossypol enantiomers for toxicity-depleted cotton seeds
JL Lin, X Fang, JX Li, ZW Chen, WK Wu, XX Guo… - Nature Plants, 2023 - nature.com
Axial chirality of biaryls can generate varied bioactivities. Gossypol is a binaphthyl
compound made by cotton plants. Of its two axially chiral isomers,(−)-gossypol is the …
compound made by cotton plants. Of its two axially chiral isomers,(−)-gossypol is the …
The nutritional and industrial significance of cottonseeds and genetic techniques in gossypol detoxification
V Ninkuu, Z Liu, Y Zhou, X Sun - Plants, People, Planet, 2024 - Wiley Online Library
Societal Impact Statement Gossypol and its derivatives represent a class of toxic and
immunosuppressive compounds that are naturally synthesized in cottonseed. These …
immunosuppressive compounds that are naturally synthesized in cottonseed. These …
Scalemic natural products
S Mazzotta, V Rositano, L Senaldi, A Bernardi… - Natural Product …, 2023 - pubs.rsc.org
Covering: up to the end of 2022The area of scalemic natural products is often enigmatic from
a mechanistic standpoint, since low optical purity is observed in compounds having multiple …
a mechanistic standpoint, since low optical purity is observed in compounds having multiple …
The potential roles of gossypol as anticancer agent: advances and future directions
D Paunovic, J Rajkovic, R Novakovic… - Chinese Medicine, 2023 - Springer
Gossypol, a polyphenolic aldehyde derived from cottonseed plants, has seen a
transformation in its pharmaceutical application from a male contraceptive to a candidate for …
transformation in its pharmaceutical application from a male contraceptive to a candidate for …
Biogenetic and biomimetic synthesis of natural bisditerpenoids: hypothesis and practices
Y Chang, C Sun, C Wang, X Huo, W Zhao… - Natural Product …, 2022 - pubs.rsc.org
Covering: up to March 2022 Bisditerpenoids, or diterpenoid dimers, are a group of natural
products with high structural variance, deriving from homo-or hetero-dimeric coupling of two …
products with high structural variance, deriving from homo-or hetero-dimeric coupling of two …
Cancer Resistance Is Mediated by the Upregulation of Several Anti-Apoptotic Gene Products via the Inducible Nitric Oxide Synthase/Nitric Oxide Pathway …
Significance: Several therapeutic strategies for cancer treatments have been developed with
time, and significant milestones have been achieved recently. However, with these novel …
time, and significant milestones have been achieved recently. However, with these novel …
Gossypol acetate: A natural polyphenol derivative with antimicrobial activities against the essential cell division protein FtsZ
RL Du, HY Chow, YW Chen, PH Chan… - Frontiers in …, 2023 - frontiersin.org
Antimicrobial resistance has attracted worldwide attention and remains an urgent issue to
resolve. Discovery of novel compounds is regarded as one way to circumvent the …
resolve. Discovery of novel compounds is regarded as one way to circumvent the …
[HTML][HTML] ML390 inhibits enterovirus 71 replication by targeting de novo pyrimidine biosynthesis pathway
Q Yang, C Wu, G Zhu, F Ren, B Lin, R Huang, X Hu… - Antiviral Research, 2023 - Elsevier
Abstract Enterovirus 71 (EV71), a small, single-stranded, positive-sense RNA virus
belonging to the enterovirus genus in the family Picornaviridae, causes hand, foot, and …
belonging to the enterovirus genus in the family Picornaviridae, causes hand, foot, and …