Selenium nanoparticles for biomedical applications: from development and characterization to therapeutics

C Ferro, HF Florindo, HA Santos - Advanced healthcare …, 2021 - Wiley Online Library
Selenium (Se) is an essential element to human health that can be obtained in nature
through several sources. In the human body, it is incorporated into selenocysteine, an amino …

Understanding of ROS‐inducing strategy in anticancer therapy

SJ Kim, HS Kim, YR Seo - Oxidative medicine and cellular …, 2019 - Wiley Online Library
Redox homeostasis is essential for the maintenance of diverse cellular processes. Cancer
cells have higher levels of reactive oxygen species (ROS) than normal cells as a result of …

Selenium interactions and toxicity: a review: selenium interactions and toxicity

I Zwolak, H Zaporowska - Cell biology and toxicology, 2012 - Springer
Selenium is an essential trace element for mammals. Through selenoproteins, this mineral
participates in various biological processes such as antioxidant defence, thyroid hormone …

Trace elements in glucometabolic disorders: an update

N Wiernsperger, JR Rapin - Diabetology & metabolic syndrome, 2010 - Springer
Many trace elements, among which metals, are indispensable for proper functioning of a
myriad of biochemical reactions, more particularly as enzyme cofactors. This is particularly …

The influence of micronutrients in cell culture: a reflection on viability and genomic stability

ALV Arigony, IM de Oliveira, M Machado… - BioMed research …, 2013 - Wiley Online Library
Micronutrients, including minerals and vitamins, are indispensable to DNA metabolic
pathways and thus are as important for life as macronutrients. Without the proper nutrients …

Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice

LA Seale, AC Hashimoto, S Kurokawa… - … and cellular biology, 2012 - Taylor & Francis
Selenium (Se) is an essential trace element used for biosynthesis of selenoproteins and is
acquired either through diet or cellular recycling mechanisms. Selenocysteine lyase (Scly) is …

Antioxidant-prooxidant properties of a new organoselenium compound library

D Plano, Y Baquedano, E Ibáñez, I Jiménez, JA Palop… - Molecules, 2010 - mdpi.com
The present study describes the biological evaluation of a library of 59 organo-selenium
compounds as superoxide (O2─) generators and cytotoxic agents in human prostate cancer …

Natural autoimmunity to selenoprotein P impairs selenium transport in Hashimoto's thyroiditis

Q Sun, S Mehl, K Renko, P Seemann… - International journal of …, 2021 - mdpi.com
The essential trace element selenium (Se) is needed for the biosynthesis of selenocysteine-
containing selenoproteins, including the secreted enzyme glutathione peroxidase 3 (GPX3) …

Understanding the redox biology of selenium in the search of targeted cancer therapies

JM Stolwijk, R Garje, JC Sieren, GR Buettner… - Antioxidants, 2020 - mdpi.com
Selenium (Se) is an essential trace nutrient required for optimal human health. It has long
been suggested that selenium has anti-cancer properties. However, clinical trials have …

Therapeutic benefits of selenium in hematological malignancies

MA Ehudin, U Golla, D Trivedi, SD Potlakayala… - International journal of …, 2022 - mdpi.com
Supplementing chemotherapy and radiotherapy with selenium has been shown to have
benefits against various cancers. This approach has also been shown to alleviate the side …