Normal testicular function is dependent upon hormones acting through endocrine and
paracrine pathways both in vivo and in vitro. Sertoli cells provide factors necessary for the …

Spermatogenesis is contingent upon hormones and growth factors acting through endocrine
and paracrine pathways either in vivo or in vitro. Sertoli cells (SCs) furnish essential factors …

In the course of mammalian spermiogenesis, a unique chromatin remodeling process takes
place within elongating and condensing spermatid nuclei. The histone-to-protamine …

Dysregulation of male germ cell apoptosis has been associated with the pathogenesis of
male infertility. Therefore, factors involved in the regulation of germ cell death are being …

Background MicroRNAs (miRNAs) play vital regulatory roles in many cellular processes.
The expression of miRNA (miR)-34c is highly enriched in adult mouse testis, but its roles …

Male reproductive health has received considerable attention in recent years. In addition to
declining sperm quality, fertility problems and increased incidence of testicular cancer, there …

BACKGROUND: Caspases are downstream elements of apoptosis-mediating pathways
initiated by the Fas ligand/Fas receptor system which is supposed to play a central role in …

The growth arrest-specific 6 gene product Gas6 is a growth and survival factor related to
protein S. Gas6 is the ligand of Axl receptor tyrosine kinase; upon binding to its receptor …

Sperm DNA fragmentation is considered one of the main causes of male infertility. The most
accepted causes of sperm DNA damage are deleterious actions of reactive oxygen species …

The growing prevalence of male infertility is a matter of serious concern. One of the putative
causes being nutritional excess from continuous consumption of high fat diet (HFD) leading …