Cellular senescence in skin‐related research: targeted signaling pathways and naturally occurring therapeutic agents

A Dańczak‐Pazdrowska, J Gornowicz‐Porowska… - Aging …, 2023 - Wiley Online Library
Despite the growing interest by researchers into cellular senescence, a hallmark of cellular
aging, its role in human skin remains equivocal. The skin is the largest and most accessible …

Diversity of fibroblasts and their roles in wound healing

D Jiang, R Guo, HG Machens… - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
Wound healing disorders are a societal, clinical, and healthcare burden and understanding
and treating them is a major challenge. A particularly important cell type in the wound …

[HTML][HTML] Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis

Y Xie, D Chen, K Jiang, L Song, N Qian, Y Du, Y Yang… - Cell Stem Cell, 2022 - cell.com
In aging, androgenic alopecia, and genetic hypotrichosis disorders, hair shaft miniaturization
is often associated with hair follicle stem cell (HFSC) loss. However, the mechanism causing …

The dermal sheath: An emerging component of the hair follicle stem cell niche

PA Martino, N Heitman, M Rendl - Experimental dermatology, 2021 - Wiley Online Library
Hair follicles cyclically regenerate throughout adult mammalian life, owing to a resident
population of epithelial hair follicle stem cells. Stem cell (SC) activity drives bouts of follicle …

Immune modulation of hair follicle regeneration

W Rahmani, S Sinha, J Biernaskie - NPJ Regenerative medicine, 2020 - nature.com
The mammalian hair follicle undergoes repeated bouts of regeneration orchestrated by a
variety of hair follicle stem cells. The last decade has witnessed the emergence of the …

Single‐cell transcriptomic analysis of small and large wounds reveals the distinct spatial organization of regenerative fibroblasts

QM Phan, S Sinha, J Biernaskie… - Experimental …, 2021 - Wiley Online Library
Wound‐induced hair follicle neogenesis (WIHN) has been an important model to study hair
follicle regeneration during wound repair. However, the cellular and molecular components …

[HTML][HTML] Microenvironmental reprogramming of human dermal papilla cells for hair follicle tissue engineering

Z Liu, J Huang, D Kang, Y Zhou, L Du, Q Qu, J Wang… - Acta Biomaterialia, 2023 - Elsevier
The restoration of hair-inductive potential in human dermal papilla cells (hDPCs) is a
tremendous challenge for hair regeneration. Much of the research thus far has indicated that …

Single-cell RNA profiling of human skin reveals age-related loss of dermal sheath cells and their contribution to a juvenile phenotype

JMD Ahlers, C Falckenhayn, N Holzscheck… - Frontiers in …, 2022 - frontiersin.org
The dermal sheath (DS) is a population of mesenchyme-derived skin cells with emerging
importance for skin homeostasis. The DS includes hair follicle dermal stem cells, which …

Collagen Hydrolysate from the Scales of Mozambique Tilapia (Oreochromis mossambicus) Improve Hair and Skin Health by Alleviating Oxidative Stress and …

SB Hwang, HJ Park, BH Lee - Marine Drugs, 2023 - mdpi.com
Fish-derived collagen hydrolysate (CH) has shown promise in improving hair and skin
health. Therefore, this study sought to comprehensively assess the effects of CH extracted …

A story of fibers and stress: Matrix‐embedded signals for fibroblast activation in the skin

M Sawant, B Hinz, K Schönborn… - Wound Repair and …, 2021 - Wiley Online Library
Our skin is continuously exposed to mechanical challenge, including shear, stretch, and
compression. The extracellular matrix of the dermis is perfectly suited to resist these …