Ratiometric optical nanoprobes enable accurate molecular detection and imaging

X Huang, J Song, BC Yung, X Huang… - Chemical Society …, 2018 - pubs.rsc.org
Exploring and understanding biological and pathological changes are of great significance
for early diagnosis and therapy of diseases. Optical sensing and imaging approaches have …

Toward quantitative surface-enhanced Raman scattering with plasmonic nanoparticles: Multiscale view on heterogeneities in particle morphology, surface …

J Son, GH Kim, Y Lee, C Lee, S Cha… - Journal of the American …, 2022 - ACS Publications
Surface-enhanced Raman scattering (SERS) provides significantly enhanced Raman
scattering signals from molecules adsorbed on plasmonic nanostructures, as well as the …

Raman spectroscopy in cell biology and microbiology

G Pezzotti - Journal of Raman Spectroscopy, 2021 - Wiley Online Library
The Raman spectrum of living cells and microorganisms contains highly specific fingerprint‐
like signatures, useful in unequivocally identifying different species and interpreting …

Potential of Raman spectroscopic techniques to study proteins

N Kuhar, S Sil, S Umapathy - Spectrochimica Acta Part A: Molecular and …, 2021 - Elsevier
Proteins are large, complex molecules responsible for various biological processes.
However, protein misfolding may lead to various life-threatening diseases. Therefore, it is …

Challenges in application of Raman spectroscopy to biology and materials

N Kuhar, S Sil, T Verma, S Umapathy - RSC advances, 2018 - pubs.rsc.org
Raman spectroscopy has become an essential tool for chemists, physicists, biologists and
materials scientists. In this article, we present the challenges in unravelling the molecule …

Label‐free molecular imaging of biological cells and tissues by linear and nonlinear Raman spectroscopic approaches

C Krafft, M Schmitt, IW Schie… - Angewandte Chemie …, 2017 - Wiley Online Library
Raman spectroscopy is an emerging technique in bioanalysis and imaging of biomaterials
owing to its unique capability of generating spectroscopic fingerprints. Imaging cells and …

Ratiometric imaging of MMP‐2 activity facilitates tumor detection using activatable near‐infrared fluorescent semiconducting polymer nanoparticles

W Zeng, L Wu, Y Sun, Y Wang, J Wang, D Ye - Small, 2021 - Wiley Online Library
Enzyme‐activatable ratiometric near‐infrared (NIR) fluorescent probes enabling
noninvasive imaging of enzyme activity in vivo are promising for biomedical research; …

Raman tweezers microspectroscopy of circa 100 nm extracellular vesicles

SG Kruglik, F Royo, JM Guigner, L Palomo, O Seksek… - Nanoscale, 2019 - pubs.rsc.org
The technique of Raman tweezers microspectroscopy (RTM) for the global biomolecular
content characterization of a single extracellular vesicle (EV) or a small number of EVs or …

In Situ Activatable Ratiometric NIR-II Fluorescence Nanoprobe for Quantitative Detection of H2S in Colon Cancer

C Wang, M Niu, W Wang, L Su, H Feng, H Lin… - Analytical …, 2021 - ACS Publications
As key characteristic molecules, several H2S-activated probes have been explored for colon
cancer studies. However, a few ratiometric fluorescence (FL) probes with NIR-II emissions …

Applications of Raman spectroscopy in the development of cell therapies: state of the art and future perspectives

S Rangan, HG Schulze, MZ Vardaki, MW Blades… - Analyst, 2020 - pubs.rsc.org
Therapies based on injecting living cells into patients offer a huge potential to cure many
degenerative and deadly diseases, with hundreds of clinical trials ongoing. Due to their …