Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and constitutes
approximately 25% of cancer diagnoses among children under the age of 15 (Howlader et …

Systemic combination chemotherapy and intrathecal chemotherapy markedly increased the
survival rate of children with ALL. In the past two decades, the use of minimal (measurable) …

Trisomy 21, the genetic cause of Down syndrome (DS), is the most common congenital
chromosomal anomaly. It is associated with a 20-fold increased risk of acute lymphoblastic …

Acute lymphoblastic leukemia (ALL) is a common malignant hematologic disease that is
characterized by large numbers of dedifferentiated lymphoid cells. Statistical data of ALL's …

Down syndrome is associated with genome-wide perturbation of gene expression, which
may be mediated by epigenetic changes. We perform an epigenome-wide association study …

Structural and numerical alterations of chromosome 21 are extremely common in
hematological malignancies. While the functional impact of chimeric transcripts from fused …

Introduction: Historically, the majority of childhood cancers, including acute lymphoblastic
leukemia (ALL), were not thought to have a hereditary basis. However, recent germline …

Background It is estimated that 300,000 children 0–19 years of age are diagnosed with
cancer worldwide each year (1). In high-income countries, cancer is the leading cause of …

Although recent studies have demonstrated associations between nonchromosomal birth
defects and several pediatric cancers, less is known about their role on childhood leukemia …

The primary cause of cisplatin resistance in liver cancer is reduced intracellular drug
accumulation and altered DNA repair/apoptosis signaling. Existing strategies to reverse …