DNA methylation is one of the most important epigenetic mechanisms to regulate gene
expression, which is highly dynamic during development and specifically maintained in …

The development and application of whole genome sequencing technology has greatly
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …

Aims Naturally secreted nanovesicles, known as exosomes, play important roles in stem cell-
mediated cardioprotection. We have previously demonstrated that atorvastatin (ATV) …

Aortic valve stenosis is the most prevalent heart valve disease worldwide. Although
interventional treatment options have rapidly improved in recent years, symptomatic aortic …

Calcific aortic valve disease (CAVD) is the most common disorder affecting heart valves and
is characterized by thickening, fibrosis and mineralization of the aortic valve leaflets …

Long non-coding RNAs (lncRNAs), a novel class of noncoding RNAs, are commonly defined
as RNA molecules more than 200 nucleotides in length. Emerging research indicated that …

Aims Emerging evidence indicates that long non-coding RNAs (lncRNAs) play a vital role in
cardiovascular physiology and pathology. Although the lncRNA TUG1 is implicated in …

Background: Long noncoding RNAs have emerged as critical molecular regulators in
various biological processes and diseases. Here we sought to identify and functionally …

Calcific aortic valve disease sits at the confluence of multiple world-wide epidemics of aging,
obesity, diabetes, and renal dysfunction, and its prevalence is expected to nearly triple over …

Abstract Objectives Long non‐coding RNAs (lncRNAs) are a group of non‐protein‐coding
RNA s that are greater than 200 nucleotides in length. Increasing evidence indicates that …