The objective of this meta-analysis is to summarize the efficacy and tolerability of the new
antipsychotics risperidone, olanzapine, sertindole and quetiapine in schizophrenia …

Background: Hypofunction of N-methyl-D-aspartate (NMDA) subtype glutamate receptor has
been implicated in the pathophysiology of schizophrenia. D-serine is a full agonist of the …

Antipsychotic drugs can be of great benefit in a range of psychiatric disorders, including
schizophrenia and bipolar disorder, but all are associated with a wide range of potential …

Dopamine (DA) holds a predominant role in the regulation of prolactin (PRL) secretion.
Through a direct effect on anterior pituitary lactotrophs, DA inhibits the basally high-secretory …

One of the most widely used guides to prescribing psychiatric medications, the Tenth Edition
of Maudsley Prescribing Guidelines returns with fully updated content and new sections on …

Quetiapine is a dibenzothiazepine derivative that has been evaluated for management of
patients with the manifestations of psychotic disorders. In pharmacokinetic studies in …

OBJECTIVE: The development of both type I and type II diabetes after initiation of some
atypical neuroleptics has been reported, primarily in studies involving small series of …

Therapeutic Drug Monitoring (TDM) is a valid tool to optimise pharmacotherapy. It enables
the clinician to adjust the dosage of drugs according to the characteristics of the individual …

“Atypical” antipsychotics are associated with a much lower propensity for extrapyramidal
side effects and, with some exceptions, a lack of sustained prolactin elevation. The authors …

Background: Numerous publications have provided evidence for clinically important
metabolic adverse effects of antipsychotics, but there is no systematic evaluation as to …