Challenges for clinical development of vaccines for prevention of hospital-acquired bacterial infections

I Bekeredjian-Ding - Frontiers in immunology, 2020 - frontiersin.org
Increasing antibiotic resistance in bacteria causing endogenous infections has entailed a
need for innovative approaches to therapy and prophylaxis of these infections and raised a …

Immune and Inflammatory Reponses to Staphylococcus aureus Skin Infections

Q Liu, M Mazhar, LS Miller - Current dermatology reports, 2018 - Springer
Abstract Purpose of Review There have been recent advances in our understanding of
cutaneous immune responses to the important human skin pathogen, Staphylococcus …

Whole-genome epidemiology, characterisation, and phylogenetic reconstruction of Staphylococcus aureus strains in a paediatric hospital

S Manara, E Pasolli, D Dolce, N Ravenni, S Campana… - Genome medicine, 2018 - Springer
Background Staphylococcus aureus is an opportunistic pathogen and a leading cause of
nosocomial infections. It can acquire resistance to all the antibiotics that entered the clinics …

Pharmacotherapeutic options for treating Staphylococcus aureus bacteremia

C Gudiol, G Cuervo, E Shaw, M Pujol… - Expert Opinion on …, 2017 - Taylor & Francis
Introduction: Case-fatality rates for Staphylococcus aureus bacteremia (SAB) remain
unacceptably high and have improved only modestly in recent decades. Treatment of SAB is …

Staphylococcus aureus Toxins: From Their Pathogenic Roles to Anti-virulence Therapy Using Natural Products

MK Kim - Biotechnology and Bioprocess Engineering, 2019 - Springer
Staphylococcus aureus (S. aureus) produces a wide variety of toxins that cause various
diseases in humans. S. aureus toxins are divided into three categories;(i) superantigens …

Identification of biologic agents to neutralize the bicomponent leukocidins of Staphylococcus aureus

R Chan, PT Buckley, A O'Malley, WE Sause… - Science translational …, 2019 - science.org
A key aspect underlying the severity of infections caused by Staphylococcus aureus is the
abundance of virulence factors that the pathogen uses to thwart critical components of the …

Antibiotic combined with epitope-specific monoclonal antibody cocktail protects mice against bacteremia and acute pneumonia from methicillin-resistant …

LL Duan, J Zhang, Z Chen, Q Gou, Q Xiong… - Journal of …, 2021 - Taylor & Francis
Purpose We previously reported that monoclonal antibody (mAb) cocktail improves survival
in Staphylococcus aureus infection. In this study, we used acute pneumonia model and …

TPST2-mediated receptor tyrosine sulfation enhances leukocidin cytotoxicity and S. aureus infection

J He, X Yang, K Yang, H Xu, C Chen, J Wang… - Frontiers in …, 2023 - frontiersin.org
Background An essential fact underlying the severity of Staphylococcus aureus (S. aureus)
infection is the bicomponent leukocidins released by the pathogen to target and lyse host …

A computational investigation of potential plant-based bioactive compounds against drug-resistant Staphylococcus aureus of multiple target proteins

S Prabha, P Chauhan, S Warkare… - Journal of Biomolecular …, 2023 - Taylor & Francis
Drug-resistant Staphylococcus aureus (DRSA) poses a significant global health threat, like
bacteremia, endocarditis, skin, soft tissue, bone, and joint infections. Nowadays, the …

Determining the immunological characteristics of a novel human monoclonal antibody developed against staphylococcal enterotoxin B

Y Liu, Z Song, S Ge, J Zhang, L Xu, F Yang… - Human Vaccines & …, 2020 - Taylor & Francis
Staphylococci are the main cause of nosocomial infections globally. The exotoxin
staphylococcal enterotoxin B (SEB) produced by methicillin-resistant Staphylococcus aureus …