Hypertriglyceridemia and atherosclerosis: using human research to guide mechanistic studies in animal models
D Basu, KE Bornfeldt - Frontiers in Endocrinology, 2020 - frontiersin.org
Human studies support a strong association between hypertriglyceridemia and
atherosclerotic cardiovascular disease (CVD). However, whether a causal relationship …
atherosclerotic cardiovascular disease (CVD). However, whether a causal relationship …
Non-mouse models of atherosclerosis: approaches to exploring the translational potential of new therapies
Cardiovascular disease is the largest single cause of disease-related mortality worldwide
and the major underlying pathology is atherosclerosis. Atherosclerosis develops as a …
and the major underlying pathology is atherosclerosis. Atherosclerosis develops as a …
Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats
Y Zhao, Y Yang, R Xing, X Cui, Y Xiao, L Xie, P You… - Atherosclerosis, 2018 - Elsevier
Background and aims Low-density lipoprotein receptor (Ldlr) and apolipoprotein E (Apoe)
knockout (KO) mice have been widely used as animal models of atherosclerosis. However …
knockout (KO) mice have been widely used as animal models of atherosclerosis. However …
Apolipoprotein E-deficient rats develop atherosclerotic plaques in partially ligated carotid arteries
S Wei, Y Zhang, L Su, K He, Q Wang, Y Zhang, D Yang… - Atherosclerosis, 2015 - Elsevier
Background The goal of this study was to establish an apolipoprotein E-deficient (ApoE-/-)
rat model. Methods The ApoE-/-rat was created by TALEN-mediated gene targeting in the …
rat model. Methods The ApoE-/-rat was created by TALEN-mediated gene targeting in the …
Hypercholesterolaemia increases the risk of high‑turnover osteoporosis in men
Y Zhou, T Deng, H Zhang, Q Guan… - Molecular …, 2019 - spandidos-publications.com
As the incidence of osteoporosis (OP) and hypercholesterolaemia in men has increased,
male OP has drawn more attention from clinicians worldwide. The present study sought to …
male OP has drawn more attention from clinicians worldwide. The present study sought to …
Long-term Western diet fed apolipoprotein E-deficient rats exhibit only modest early atherosclerotic characteristics
In the apolipoprotein E–deficient mouse, the gut microbiota has an impact on the
development of atherosclerosis, but whether such correlations are also present in rats …
development of atherosclerosis, but whether such correlations are also present in rats …
[HTML][HTML] Establishment of a rat model with diet-induced coronary atherosclerosis
M Gao, G Xin, X Qiu, Y Wang, G Liu - Journal of Biomedical …, 2017 - ncbi.nlm.nih.gov
Coronary atherosclerotic disease is a serious disease in humans, but no suitable animal
model is available currently for further studies. We used apolipoprotein E gene knockout …
model is available currently for further studies. We used apolipoprotein E gene knockout …
Apolipoprotein E deficient rats generated via zinc-finger nucleases exhibit pronounced in-stent restenosis
The long-term success of coronary stent implantation is limited by in-stent restenosis (ISR).
In spite of a broad variety of animal models available, an ideal high-throughput model of ISR …
In spite of a broad variety of animal models available, an ideal high-throughput model of ISR …
[HTML][HTML] A longitudinal 18F-fluorodeoxyglucose (18F-FDG) and 18F-sodium fluoride (18F-NaF) positron emission tomography/computed tomography (PET/CT) study …
X Zhuang, Y Feng, J Li, F Zhao, Y Zhang… - … Diagnosis and Therapy, 2021 - ncbi.nlm.nih.gov
Background Inflammation and vascular calcification are risk factors for cardiovascular
disease, but their relationship is still under investigation. This longitudinal in vivo study …
disease, but their relationship is still under investigation. This longitudinal in vivo study …
Characterization of a novel model for atherosclerosis imaging: the apolipoprotein E-deficient rat
JWA Sijbesma, A van Waarde, S Kristensen, I Kion… - EJNMMI research, 2023 - Springer
Background The apolipoprotein E-deficient (apoE−/−) mouse is a well-established model for
studying atherosclerosis. However, its small size limits its use in longitudinal positron …
studying atherosclerosis. However, its small size limits its use in longitudinal positron …