Human studies support a strong association between hypertriglyceridemia and
atherosclerotic cardiovascular disease (CVD). However, whether a causal relationship …

Cardiovascular disease is the largest single cause of disease-related mortality worldwide
and the major underlying pathology is atherosclerosis. Atherosclerosis develops as a …

Background and aims Low-density lipoprotein receptor (Ldlr) and apolipoprotein E (Apoe)
knockout (KO) mice have been widely used as animal models of atherosclerosis. However …

Background The goal of this study was to establish an apolipoprotein E-deficient (ApoE-/-)
rat model. Methods The ApoE-/-rat was created by TALEN-mediated gene targeting in the …

As the incidence of osteoporosis (OP) and hypercholesterolaemia in men has increased,
male OP has drawn more attention from clinicians worldwide. The present study sought to …

In the apolipoprotein E–deficient mouse, the gut microbiota has an impact on the
development of atherosclerosis, but whether such correlations are also present in rats …

Coronary atherosclerotic disease is a serious disease in humans, but no suitable animal
model is available currently for further studies. We used apolipoprotein E gene knockout …

The long-term success of coronary stent implantation is limited by in-stent restenosis (ISR).
In spite of a broad variety of animal models available, an ideal high-throughput model of ISR …

Background Inflammation and vascular calcification are risk factors for cardiovascular
disease, but their relationship is still under investigation. This longitudinal in vivo study …

Background The apolipoprotein E-deficient (apoE−/−) mouse is a well-established model for
studying atherosclerosis. However, its small size limits its use in longitudinal positron …