Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential
X Xu, Q Peng, X Jiang, S Tan, Y Yang… - … & Molecular Medicine, 2023 - nature.com
Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …
[HTML][HTML] Stress, diet, exercise: common environmental factors and their impact on epigenetic age
F Galkin, O Kovalchuk, D Koldasbayeva… - Ageing Research …, 2023 - Elsevier
Epigenetic aging clocks have gained significant attention as a tool for predicting age-related
health conditions in clinical and research settings. They have enabled geroscientists to …
health conditions in clinical and research settings. They have enabled geroscientists to …
Epigenetic regulation of hybrid epithelial-mesenchymal cell states in cancer
RA Sample, MF Nogueira, RD Mitra, SV Puram - Oncogene, 2023 - nature.com
Epithelial-to-mesenchymal transition (EMT) is a process by which cells lose their epithelial
characteristics and gain mesenchymal phenotypes. In cancer, EMT is thought to drive tumor …
characteristics and gain mesenchymal phenotypes. In cancer, EMT is thought to drive tumor …
How to slow down the ticking clock: age-associated epigenetic alterations and related interventions to extend life span
Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …
overview on recent findings describing the epigenetic changes that arise during aging and …
[HTML][HTML] A review of biological targets and therapeutic approaches in the management of triple-negative breast cancer
Background Triple-negative breast cancer (TNBC) is a heterogeneous, aggressive
phenotype of breast cancer with associated chemoresistance. The development of chemo-or …
phenotype of breast cancer with associated chemoresistance. The development of chemo-or …
Epigenetic regulation of cancer-associated fibroblast heterogeneity
RJ Kehrberg, N Bhyravbhatla, SK Batra… - Biochimica et Biophysica …, 2023 - Elsevier
Abstract Cancer-associated fibroblasts (CAFs), a significant component of the tumor
microenvironment (TME), contribute to cancer progression through the secretion of …
microenvironment (TME), contribute to cancer progression through the secretion of …
Sources of cancer neoantigens beyond single-nucleotide variants
The success of checkpoint blockade therapy against cancer has unequivocally shown that
cancer cells can be effectively recognized by the immune system and eliminated. However …
cancer cells can be effectively recognized by the immune system and eliminated. However …
[图书][B] Molecular biology of human cancers
WA Schulz - 2023 - Springer
viii everybody who contributed to the first edition. As always, I have to thank my wife and
family for encouragement and support (as well as patience…). I hope you will find this book …
family for encouragement and support (as well as patience…). I hope you will find this book …
Novel systemic treatment modalities including immunotherapy and molecular targeted therapy for recurrent and metastatic head and neck squamous cell carcinoma
Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancers
worldwide. More than half of patients with HNSCC eventually experience disease …
worldwide. More than half of patients with HNSCC eventually experience disease …
Current trends in development of HDAC-based chemotherapeutics
Abstract Background Histone deacetylases (HDACs) are one of the essential epigenetic
targets in cancer treatment. These enzymes play key roles in post-translation modification …
targets in cancer treatment. These enzymes play key roles in post-translation modification …