Breast cancer is the most common noncutaneous malignancy and the second most lethal
form of cancer among women in the United States. It currently affects more than one in ten …

Breast cancer is the second leading cause of cancer related deaths among women aged 40–
55 in the United States and currently affects more than one in ten women worldwide. It is …

Pulmonary hypertension (PH) encompasses a syndrome of diseases that are characterized
by elevated pulmonary artery pressure and pulmonary vascular remodeling and that …

Breast cancer is the most common malignancy in women in the United States but significant
disparities exist for African American women compared to Caucasian women. African …

Cytochrome P450s are enzymes which catalyze Phase-I metabolism reactions; cytochrome
P450 1A1 (CYP1A1) is a member of the CYP1 family and participates in the metabolism of a …

Sex hormones are linked to right ventricular (RV) function, but the relationship between
genetic variation in these pathways and RV function is unknown. We performed a cross …

Although increased awareness leading to early detection and prevention, as well as
advancements in treatment strategies, have resulted in superior clinical outcomes, African …

Abstract Purpose of Review Prevalence and outcome differences between women and men
with pulmonary arterial hypertension (PAH) raise questions about the role of sex hormones …

To date, no targeted therapies are available to treat triple negative breast cancer (TNBC),
while other breast cancer subtypes are responsive to current therapeutic treatment …

Abstract CYP450 3A4 (CYP3A4), encoded by the CYP3A4 gene, is a major enzyme
catalyzing the metabolism of both endogenous and exogenous agents that may play a role …