Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

Progressive neuronal loss is a hallmark of many neurodegenerative diseases, including
Alzheimer's and Parkinson's disease. These pathologies exhibit clear signs of inflammation …

Abnormal aggregation of α-synuclein is thought to be one of core pathogenic factors in PD.
Ca2+ can bind to the C-terminus of α-synuclein, regulate the secretion of α-synuclein, and …

Objectives Isradipine is a dihydropyridine calcium channel inhibitor that has demonstrated
concentration‐dependent neuroprotective effects in animal models of Parkinson's disease …

The loss of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SN)
underlies the core motor symptoms of the progressive movement disorder Parkinson's …

A major hallmark of Parkinson's disease (PD) is the fatal destruction of dopaminergic
neurons within the substantia nigra pars compacta. This event is preceded by the formation …

NR2D subunit-containing NMDA receptors (NMDARs) gradually disappear during brain
maturation but can be recruited by pathophysiological stimuli in the adult brain. Here, we …

Mitochondrial dysfunction and reactive oxygen species (ROS) accumulation within the
substantia nigra pars compacta (SNpc) are central drivers of dopaminergic (DA) neuron …

Abstract Calcium (Ca 2+) plays a central role in regulating many cellular processes and
influences cell survival. Several mechanisms can disrupt Ca 2+ homeostasis to trigger cell …

Neurological disorders are the leading cause of cognitive and physical disability worldwide,
affecting 15% of the global population. Due to the demographics of aging, the prevalence of …