A comprehensive review on the role of the gut microbiome in human neurological disorders

SG Sorboni, HS Moghaddam… - Clinical microbiology …, 2022 - Am Soc Microbiol
The human body is full of an extensive number of commensal microbes, consisting of
bacteria, viruses, and fungi, collectively termed the human microbiome. The initial …

The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders

GZ Réus, GR Fries, L Stertz, M Badawy, IC Passos… - Neuroscience, 2015 - Elsevier
Psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD) and
schizophrenia, affect a significant percentage of the world population. These disorders are …

Glial cells in schizophrenia: a unified hypothesis

AG Dietz, SA Goldman, M Nedergaard - The Lancet Psychiatry, 2020 - thelancet.com
The cellular neurobiology of schizophrenia remains poorly understood. We discuss
neuroimaging studies, pathological findings, and experimental work supporting the idea that …

Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review

MO Trépanier, KE Hopperton, R Mizrahi… - Molecular …, 2016 - nature.com
Schizophrenia is a psychiatric disorder which has a lifetime prevalence of~ 1%. Multiple
candidate mechanisms have been proposed in the pathogenesis of schizophrenia. One …

Biological hypotheses, risk factors, and biomarkers of schizophrenia

Z Fišar - Progress in Neuro-Psychopharmacology and …, 2023 - Elsevier
Both the discovery of biomarkers of schizophrenia and the verification of biological
hypotheses of schizophrenia are an essential part of the process of understanding the …

Meta-analysis of the association of urbanicity with schizophrenia

E Vassos, CB Pedersen, RM Murray… - Schizophrenia …, 2012 - academic.oup.com
The association between urbanicity and risk of schizophrenia is well established. The
incidence of schizophrenia has been observed to increase in line with rising levels of …

Incidence of schizophrenia and other psychoses in England, 1950–2009: a systematic review and meta-analyses

JB Kirkbride, A Errazuriz, TJ Croudace, C Morgan… - PloS one, 2012 - journals.plos.org
Background We conducted a systematic review of incidence rates in England over a sixty-
year period to determine the extent to which rates varied along accepted (age, sex) and less …

Uncovering the roles of rare variants in common disease through whole-genome sequencing

ET Cirulli, DB Goldstein - Nature Reviews Genetics, 2010 - nature.com
Although genome-wide association (GWA) studies for common variants have thus far
succeeded in explaining only a modest fraction of the genetic components of human …

Schizophrenia,“just the facts” 4. Clinical features and conceptualization

R Tandon, HA Nasrallah, MS Keshavan - Schizophrenia research, 2009 - Elsevier
Although dementia praecox or schizophrenia has been considered a unique disease entity
for the past century, its definitions and boundaries have continued to vary over this period. At …

A meta-analysis of the risk for psychotic disorders among first-and second-generation immigrants

F Bourque, E van der Ven, A Malla - Psychological medicine, 2011 - cambridge.org
BackgroundThere is increasing acceptance of migration as a risk factor for schizophrenia
and related disorders; however, the magnitude of the risk among second-generation …