[HTML][HTML] m6A modification in coding and non-coding RNAs: roles and therapeutic implications in cancer

H Huang, H Weng, J Chen - Cancer cell, 2020 - cell.com
N 6-Methyladenosine (m 6 A) RNA modification has emerged in recent years as a new layer
of regulatory mechanism controlling gene expression in eukaryotes. As a reversible …

[HTML][HTML] The potential role of RNA N6-methyladenosine in Cancer progression

T Wang, S Kong, M Tao, S Ju - Molecular cancer, 2020 - Springer
Abstract N6-methyladenosine (m6A) is considered the most common, abundant, and
conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA) …

[HTML][HTML] Roles of METTL3 in cancer: mechanisms and therapeutic targeting

C Zeng, W Huang, Y Li, H Weng - Journal of hematology & oncology, 2020 - Springer
Abstract N 6-methyladenosine (m 6 A) is the most abundant mRNA modification and is
catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is …

[HTML][HTML] Insights into N6-methyladenosine and programmed cell death in cancer

L Liu, H Li, D Hu, Y Wang, W Shao, J Zhong, S Yang… - Molecular cancer, 2022 - Springer
Abstract N6-methyladenosine (m6A) methylation, the most common form of internal RNA
modification in eukaryotes, has gained increasing attention and become a hot research topic …

[HTML][HTML] Role of m6A writers, erasers and readers in cancer

Z Fang, W Mei, C Qu, J Lu, L Shang, F Cao… - … Hematology & Oncology, 2022 - Springer
Abstract The N (6)-methyladenosine (m6A) modification is the most pervasive modification of
human RNAs. In recent years, an increasing number of studies have suggested that m6A …

[HTML][HTML] N6-methyladenosine methyltransferases: functions, regulation, and clinical potential

W Huang, TQ Chen, K Fang, ZC Zeng, H Ye… - Journal of Hematology & …, 2021 - Springer
Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …

[HTML][HTML] METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer

X Chen, MU Xu, X Xu, K Zeng, X Liu, B Pan, C Li… - Molecular cancer, 2020 - Springer
Background Colorectal cancer (CRC) is one of the leading causes of tumor-related death
worldwide, and its main cause of death is distant metastasis. Methyltransferase-like 14 …

[HTML][HTML] The m6A readers YTHDF1 and YTHDF3 aberrations associated with metastasis and predict poor prognosis in breast cancer patients

R Anita, A Paramasivam, JV Priyadharsini… - American journal of …, 2020 - ncbi.nlm.nih.gov
Abstract N6-Methyladenosine (m6A) is the most common RNA modification in eukaryotic
mRNAs and growing evidence suggests the crucial roles of m6A and its regulators in human …

[HTML][HTML] Mechanism of RNA modification N6-methyladenosine in human cancer

Z Zhou, J Lv, H Yu, J Han, X Yang, D Feng, Q Wu… - Molecular cancer, 2020 - Springer
Since the breakthrough discoveries of DNA and histone modifications, the field of RNA
modifications has gained increasing interest in the scientific community. The discovery of N6 …

[HTML][HTML] Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance

H Lin, Y Wang, P Wang, F Long, T Wang - Molecular cancer, 2022 - Springer
The resistance of tumor cells to therapy severely impairs the efficacy of treatment, leading to
recurrence and metastasis of various cancers. Clarifying the underlying mechanisms of …