Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Natural products, and especially the active ingredients found in traditional Chinese medicine
(TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in …

Antimicrobial resistance poses a substantial threat to human health. The gut microbiome is
considered a reservoir for potential spread of resistance genes from commensals to …

The prevalence of metabolic diseases, including obesity, dyslipidemia, type 2 diabetes
mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD), is a severe burden in human …

Background Polyphenols are a class of naturally sourced compounds with widespread
distribution and an extensive array of bioactivities. However, due to their complex …

Alkaloids are one of the most important classes of plant bioactives. Among these
isoquinoline alkaloids possess varied structures and exhibit numerous biological activities …

Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance
and perturbations of the developing microbiome. Early-life microbiome disruption increases …

Gut microbiota has attracted widespread attention due to its crucial role in disease
pathophysiology, including type 2 diabetes mellitus (T2DM). Metabolites and bacterial …

Diabetes mellitus is a chronic multifaceted disease with multiple potential complications, the
treatment of which can only delay and prolong the terminal stage of the disease, ie, type 2 …

The gut microbiota and its homeostasis play a crucial role in human health. However, for
some diseases related to the gut microbiota, current traditional medicines can only relieve …