Antibiotics: A “GOLDen” promise?
Bacterial infections pose a significant threat to public health and the global economy. The
misuse of antibiotics in the treatment of bacterial infections has led to a rapid development of …
misuse of antibiotics in the treatment of bacterial infections has led to a rapid development of …
Gold(I) N‐heterocyclic carbene (NHC) complexes containing 6‐mercaptopurine derivatives and their in vitro anticancer and anti‐inflammatory effects
A series of eight N‐heterocyclic carbenes (NHC) gold (I) complexes, involving 1, 3‐bis (2, 6‐
diisopropylphenyl) imidazol‐2‐ylidene (iPr) ligand in combination with 6‐mercaptopurine …
diisopropylphenyl) imidazol‐2‐ylidene (iPr) ligand in combination with 6‐mercaptopurine …
Ferroptosis resistance in cancer: Recent advances and future perspectives
X Zhang, X Li, R Xia, HS Zhang - Biochemical Pharmacology, 2023 - Elsevier
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death and has been
implicated in the occurrence and development of various diseases, including heart disease …
implicated in the occurrence and development of various diseases, including heart disease …
Discovery of novel organoarsenicals as robust thioredoxin reductase inhibitors for oxidative stress mediated cancer therapy
W She, X Shi, T Liu, Y Liu, Y Liu - Biochemical Pharmacology, 2023 - Elsevier
Targeting overexpressed thioredoxin reductase (TrxR) in cancer cells to induce oxidative
stress has been proved to be an effective strategy for cancer therapy. However, the …
stress has been proved to be an effective strategy for cancer therapy. However, the …
Gold (I) N-Heterocyclic Carbene Complexes with 7-Azaindoles Demonstrates In Vitro Antiproliferative Effects on Ovarian Cancer Cells and Anti-inflammatory Activity
The gold (I) N-heterocyclic carbene (NHC) complexes, containing a combination of 1, 3-bis
(2, 6-diisopropylphenyl) imidazole-2-ylidene (iPr) and the corresponding 7-azaindole …
(2, 6-diisopropylphenyl) imidazole-2-ylidene (iPr) and the corresponding 7-azaindole …
S–Se oxidative addition to auranofin derivatives: a DFT study
HF Dos Santos, DFS Paschoal - Physical Chemistry Chemical Physics, 2024 - pubs.rsc.org
Oxidative addition of the S–Se bond to Au (I) complexes is discussed for a series of 26
auranofin (AF) derivatives. AF and its analogues are Au (I) complexes with recognized …
auranofin (AF) derivatives. AF and its analogues are Au (I) complexes with recognized …
[HTML][HTML] The binding of auranofin at DNA/RNA nucleobases: A DFT assessment
A variety of therapies are based on cytotoxicity induced via hampering the DNA and/or RNA
homeostasis. The metallodrugs' forerunner, cisplatin, is exemplificative of the tremendous …
homeostasis. The metallodrugs' forerunner, cisplatin, is exemplificative of the tremendous …
Ligand supplementation restores the cancer therapy efficacy of an antirheumatic drug auranofin from serum inactivation
Y Wang, B Cao, Q Wang, X Fang, J Wang, ASC Chan… - bioRxiv, 2024 - biorxiv.org
Auranofin, an FDA-approved antirheumatic gold drug, has gained ongoing interest in clinical
studies for treating advanced or recurrent tumors. However, gold ion's dynamic thiol …
studies for treating advanced or recurrent tumors. However, gold ion's dynamic thiol …
Ouro na terapia anticâncer: compostos organometálicos com ligantes ditiocarbamato e nanopartículas solúveis estabilizadas por carbeno N-heterocíclico
AL de Andrade Querino - 2023 - repositorio.ufmg.br
A descoberta das propriedades medicinais dos compostos de ouro impulsionou o design e
a síntese de novos metalo-fármacos para a terapia anticâncer. No presente trabalho …
a síntese de novos metalo-fármacos para a terapia anticâncer. No presente trabalho …
Gold (I) N-heterocyclic Carbene Complexes with 7-Azaindoles Demonstrate In Vitro Antiproliferative Effects on Ovarian Cancer Cells and Anti-inflammatory Activity
The gold (I) N-heterocyclic carbene (NHC) complexes, containing a combination of 1, 3-bis
(2, 6-diisopropylphenyl) imidazol-2-ylidene (iPr) and the corresponding 7-azaindole …
(2, 6-diisopropylphenyl) imidazol-2-ylidene (iPr) and the corresponding 7-azaindole …