Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

Polymyxins are well-established antibiotics that have recently regained significant interest
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …

Background The β-lactamase inhibitor relebactam can restore imipenem activity against
imipenem-nonsusceptible gram-negative pathogens. We evaluated imipenem/relebactam …

Objectives Plasmid-mediated mobilized colistin resistance is currently known to be caused
by phosphoethanolamine transferases termed MCR-1, MCR-2, MCR-3 and MCR-4 …

Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …

The emergence and spread of antibiotic-resistant pathogens is a major public health issue,
which requires global action of an intersectoral nature. Multidrug-resistant (MDR) pathogens …

Colistin (Polymyxin E) is one of the few cationic antimicrobial peptides commercialized in
both human and veterinary medicine. For several years now, colistin has been considered …

Background: Infections caused by multi-drug-resistant Gram-negative bacteria, particularly
Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae, that …

This article provides a comprehensive review of currently available treatment options for
infections due to carbapenem-resistant Enterobacteriaceae (CRE). Antimicrobial resistance …

Increasing antibiotic resistance in Gram-negative bacteria, particularly in Pseudomonas
aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae, presents a global …