Aminoacyl-tRNA synthetases (ARSs) are enzymes that catalyze the ligation of amino acids
to tRNAs for translation. Beyond their traditional role in translation, ARSs have acquired …

Over the last two decades, global malaria cases caused by Plasmodium falciparum have
declined due to the implementation of effective treatments and the use of insecticides …

Plasmodium parasite resistance to existing antimalarial drugs poses a devastating threat to
the lives of many who depend on their efficacy. New antimalarial drugs and novel drug …

Malaria poses an enormous threat to human health. With ever increasing resistance to
currently deployed drugs, breakthrough compounds with novel mechanisms of action are …

Increasing numbers of antimalarial compounds are being identified that converge
mechanistically at inhibition of cytoplasmic translation, regardless of the molecular target or …

Protein synthesis is a core cellular process, necessary throughout the complex lifecycle of
Plasmodium parasites, thus specific translation inhibitors would be a valuable class of …

Malaria is a vector-transmitted disease and contributes significantly to mortality rates
worldwide. However, utilizing the available synthetic antimalarial compounds is challenging …

Plasmodium parasite resistance to antimalarial drugs is a serious threat to public health in
malaria-endemic areas. Compounds that target core cellular processes like translation are …