The potential contributions of chronic inflammation to lung carcinogenesis
S Ballaz, JL Mulshine - Clinical lung cancer, 2003 - Elsevier
A number of lines of evidence suggests that chronic inflammation contributes to the process
of carcinogenesis. In this article, this theme is explored with particular emphasis on the …
of carcinogenesis. In this article, this theme is explored with particular emphasis on the …
Carcinogenesis and cyclooxygenase: the potential role of COX-2 inhibition in upper aerodigestive tract cancer
S Mohan, JB Epstein - Oral oncology, 2003 - Elsevier
Cyclooxygenase-2 (COX-2) is upregulated in a number of epithelial cancers, including in
upper aerodigestive tract (UADT) premalignant and malignant lesions. The purpose of this …
upper aerodigestive tract (UADT) premalignant and malignant lesions. The purpose of this …
Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer
CA Martey, SJ Pollock, CK Turner… - … of Physiology-Lung …, 2004 - journals.physiology.org
Cigarette smoking can lead to many human pathologies including cardiovascular and
respiratory disease. Recent studies have defined a role for fibroblasts in the development of …
respiratory disease. Recent studies have defined a role for fibroblasts in the development of …
Randomized phase III trial of low-dose isotretinoin for prevention of second primary tumors in stage I and II head and neck cancer patients
Abstract Background: Isotretinoin (13-cis-retinoic acid) is a synthetic vitamin A derivative, or
retinoid, widely used in the treatment of cystic acne. Preclinical and clinical studies of high …
retinoid, widely used in the treatment of cystic acne. Preclinical and clinical studies of high …
[HTML][HTML] Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2
D Mukhopadhyay, CW Houchen, S Kennedy… - Molecular cell, 2003 - cell.com
Abstract Cyclooxygenase-2 (COX-2) expression is translationally silenced in epithelial cells
undergoing radiation-induced apoptosis. CUGBP2, a predominantly nuclear protein, is also …
undergoing radiation-induced apoptosis. CUGBP2, a predominantly nuclear protein, is also …
[HTML][HTML] The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by …
MC Chang, HL Wu, JJ Lee, PH Lee, HH Chang… - Journal of Biological …, 2004 - ASBMB
There are about 200–600 million betel quid (BQ) chewers in the world. BQ chewing is one of
the major risk factor of hepatocarcinoma, oropharyngeal, and esophagus cancers in Taiwan …
the major risk factor of hepatocarcinoma, oropharyngeal, and esophagus cancers in Taiwan …
[HTML][HTML] Regulation of COX-2 protein expression by Akt in endometrial cancer cells is mediated through NF-κB/IκB pathway
Abstract Background Cyclooxygenase-2 (COX-2) has been shown to be highly expressed in
a broad series of primary endometrial tumors and its expression may be closely associated …
a broad series of primary endometrial tumors and its expression may be closely associated …
Randomized, double-blind, placebo-controlled phase IIb trial of the cyclooxygenase inhibitor ketorolac as an oral rinse in oropharyngeal leukoplakia
JL Mulshine, JC Atkinson, RO Greer… - Clinical cancer …, 2004 - AACR
Purpose: Nonselective cyclooxygenase (COX) inhibitors have been reported to decrease
the frequency of upper aerodigestive cancers. Ketorolac tromethamine oral rinse has been …
the frequency of upper aerodigestive cancers. Ketorolac tromethamine oral rinse has been …
The role of the AU-rich elements of mRNAs in controlling translation
E Espel - Seminars in cell & developmental biology, 2005 - Elsevier
Adenosine-and uridine-rich elements (AREs) located in 3′-untranslated regions are the
best-known determinants of RNA instability. These elements have also been shown to …
best-known determinants of RNA instability. These elements have also been shown to …
Therapeutic potential of selective cyclooxygenase-2 inhibitors in the management of tumor angiogenesis
Therapeutic strategies for the treatment and management of neoplastic diseases have
largely focused on the cancer cell. These approaches have achieved only limited success …
largely focused on the cancer cell. These approaches have achieved only limited success …