Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate
subunit-a cyclin-that provides domains essential for enzymatic activity. CDKs play important …

Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle
and transcription, as well as communication, metabolism, and apoptosis. The kinases are …

DNA is one of the prime molecules, and its stability is of utmost importance for proper
functioning and existence of all living systems. Genotoxic chemicals and radiations exert …

Over the past few years, media have popularized the story of the “children of the moon” who
must remain in the dark and avoid exposure to sunlight. 1r3 These children suffer from a rare …

Cellular information processing via reversible protein phosphorylation requires tight control
of the localization, activity, and substrate specificity of protein kinases, which to a large …

Nucleotide excision repair (NER) is the most versatile mechanism of DNA repair,
recognizing and dealing with a variety of helix-distorting lesions, such as the UV-induced …

In metazoans, cyclin-dependent kinase 7 (CDK7) has essential roles in both the cell-division
cycle and transcription, as a CDK-activating kinase (CAK) and as a component of the …

The TFIIH multiprotein complex is organized into a 7-subunit core associated with a 3-
subunit CDK-activating kinase module (CAK). Three enzymatic subunits are present in …

The XPD helicase (Rad3 in Saccharomyces cerevisiae) is a component of transcription
factor IIH (TFIIH), which functions in transcription initiation and Nucleotide Excision Repair in …

The Cyclin-dependent kinase (CDK) Activating Kinase (CAK) is responsible for the
activating phosphorylation of CDK1, CDK2, CDK4 and CDK6 and regulation of the cell …