The orbitofrontal cortex, food intake and obesity

LT Seabrook, SL Borgland - Journal of Psychiatry and Neuroscience, 2020 - jpn.ca
Obesity is a major health challenge facing many people throughout the world. Increased
consumption of palatable, high-caloric foods is one of the major drivers of obesity. Both …

[HTML][HTML] A literature review of dopamine in binge eating

Y Yu, R Miller, SW Groth - Journal of Eating Disorders, 2022 - Springer
Objective Binge eating, a core diagnostic symptom in binge eating disorder and bulimia
nervosa, increases the risk of multiple physiological and psychiatric disorders. The …

Influence of the gut microbiota on satiety signaling

JJAJ Bastings, K Venema, EE Blaak… - Trends in Endocrinology & …, 2023 - cell.com
Recent studies show a link between the gut microbiota and the regulation of satiety and
energy intake, processes that contribute to the development and pathophysiology of …

Obesity and responsibility: Is it time to rethink agency?

A Grannell, F Fallon, W Al‐Najim, C le Roux - Obesity Reviews, 2021 - Wiley Online Library
Despite obesity declared a disease, there still exists considerable weight stigma in both
popular culture and health care, which negatively impacts policy making regarding …

[HTML][HTML] A systematic review of genetic polymorphisms associated with binge eating disorder

L Manfredi, A Accoto, A Couyoumdjian, D Conversi - Nutrients, 2021 - mdpi.com
The genetic polymorphisms involved in the physiopathology of binge eating disorder (BED)
are currently unclear. This systematic review aims to highlight and summarize the research …

[HTML][HTML] High fat diet suppresses peroxisome proliferator-activated receptors and reduces dopaminergic neurons in the substantia nigra

YC Kao, WY Wei, KJ Tsai, LC Wang - International journal of molecular …, 2019 - mdpi.com
Although several epidemiologic and animal studies have revealed correlations between
obesity and neurodegenerative disorders, such as Parkinson disease (PD), the underlying …

[HTML][HTML] GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans

R Hanssen, AC Kretschmer, L Rigoux, K Albus… - Molecular …, 2021 - Elsevier
Objective To regulate food intake, our brain constantly integrates external cues, such as the
incentive value of a potential food reward, with internal state signals, such as hunger …

Removal of high-fat diet after chronic exposure drives binge behavior and dopaminergic dysregulation in female mice

JL Carlin, SE McKee, T Hill-Smith, NM Grissom… - Neuroscience, 2016 - Elsevier
A significant contributor to the obesity epidemic is the overconsumption of highly palatable,
energy dense foods. Chronic intake of palatable foods is associated with neuroadaptations …

[HTML][HTML] High fructose corn syrup induces metabolic dysregulation and altered dopamine signaling in the absence of obesity

AM Meyers, D Mourra, JA Beeler - PloS one, 2017 - journals.plos.org
The contribution of high fructose corn syrup (HFCS) to metabolic disorder and obesity,
independent of high fat, energy-rich diets, is controversial. While high-fat diets are widely …

[HTML][HTML] The rise and fall of dopamine: a two-stage model of the development and entrenchment of anorexia nervosa

JA Beeler, NS Burghardt - Frontiers in psychiatry, 2022 - frontiersin.org
Dopamine has long been implicated as a critical neural substrate mediating anorexia
nervosa (AN). Despite nearly 50 years of research, the putative direction of change in …