Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that manifests as
cognitive deficits and memory decline, especially in old age. Several biomarkers have been …

Objectives The prevalence of sensory impairment at an early stage of amyotrophic lateral
sclerosis (ALS) is still debated. The study aim was to investigate the anatomofunctional …

A preferential loss of retinal ganglion cells (RGCs) is observed in glaucoma and optic
neuritis. Loss of tropomyosin-related kinase receptor B (TrkB)-mediated signaling has been …

Optic neuropathy refers to dysfunction and/or degeneration of axons of the optic nerve with
subsequent optic nerve atrophy. A common feature of different optic neuropathies is retinal …

SH2 domain containing tyrosine phosphatase 2 (Shp2; PTPN11) regulates several
intracellular pathways downstream of multiple growth factor receptors. Our studies implicate …

Current evidence suggests that exposure to chronically induced intraocular pressure (IOP)
leads to neurodegenerative changes in the inner retina. This study aimed to determine …

Objective To examine the effect of chronic demyelination in the optic nerve of patients with
MS on progressive loss of retinal ganglion cell (RGC) axons. Methods Progressive retinal …

The transcription factors CREB (cAMP response element binding factor), SRF (serum
response factor), and MEF2 (myocyte enhancer factor 2) play critical roles in the …

Neuroserpin is a serine protease inhibitor that regulates the activity of plasmin and its
activators in the neuronal tissues. This study provides novel evidence of regulatory effect of …