Electrochemical late-stage functionalization
Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or
diversification of novel molecular entities with improved physicochemical or biological …
diversification of novel molecular entities with improved physicochemical or biological …
The crucial role of silver (I)-salts as additives in C–H activation reactions: overall analysis of their versatility and applicability
RL de Carvalho, EBT Diogo, SL Homölle… - Chemical Society …, 2023 - pubs.rsc.org
Transition-metal catalyzed C–H activation reactions have been proven to be useful
methodologies for the assembly of synthetically meaningful molecules. This approach bears …
methodologies for the assembly of synthetically meaningful molecules. This approach bears …
Scalable electrosynthesis of commodity chemicals from biomass by suppressing non-Faradaic transformations
H Zhou, Y Ren, B Yao, Z Li, M Xu, L Ma, X Kong… - Nature …, 2023 - nature.com
Electrooxidation of biomass platforms provides a sustainable route to produce valuable
oxygenates, but the practical implementation is hampered by the severe carbon loss …
oxygenates, but the practical implementation is hampered by the severe carbon loss …
One-pot H/D exchange and low-coordinated iron electrocatalyzed deuteration of nitriles in D2O to α,β-deuterio aryl ethylamines
Developing a step-economical approach for efficient synthesis of α, β-deuterio aryl
ethylamines (α, β-DAEAs) with high deuterium ratios using an easy-to-handle deuterated …
ethylamines (α, β-DAEAs) with high deuterium ratios using an easy-to-handle deuterated …
Supporting-electrolyte-free electrochemical [2+ 2+ 1] annulation of benzo [d] isothiazole 1, 1-dioxides, N-arylglycines and paraformaldehyde
HY Song, J Jiang, YH Song, MH Zhou, C Wu… - Chinese Chemical …, 2024 - Elsevier
The H-bond promoted electrochemical [2+ 2+ 1] annulation of benzo [d] isothiazole 1, 1-
dioxides, N-arylglycines and paraformaldehyde for the synthesis of various benzo [d] …
dioxides, N-arylglycines and paraformaldehyde for the synthesis of various benzo [d] …
Cp2Fe Mediated Electrochemical Synthesis of Phosphonylated Spirocyclic Indolines via Dearomatization of Indoles
K Mo, X Zhou, J Wang, J Wu, Y Zhao - Organic Letters, 2023 - ACS Publications
A general and robust strategy for the synthesis of phosphonylated spirocyclic indolines has
been developed through Cp2Fe-catalyzed electrochemical dearomaztizaion of indoles …
been developed through Cp2Fe-catalyzed electrochemical dearomaztizaion of indoles …
An update on late-stage functionalization in today's drug discovery
AP Montgomery, JM Joyce, JJ Danon… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction Late-stage functionalization (LSF) allows for the introduction of new chemical
groups toward the end of a synthetic sequence, which means new molecules can be rapidly …
groups toward the end of a synthetic sequence, which means new molecules can be rapidly …
An approach for the synthesis of 2-aryl-3-sulfonyl substituted quinolines through an electrochemical cascade annulation pathway
An electrochemical protocol for the synthesis of 2, 3-disubstituted quinolines by reacting
benzoxazinones with arylsulfonyl hydrazides was established under simple and mild …
benzoxazinones with arylsulfonyl hydrazides was established under simple and mild …
Electrochemical Oxidative Phosphorylations of Glycine Derivatives with R2P(O)−H‐Containing Compounds via C(sp3)−H Functionalisation
A transition-metal catalyst-and external oxidant-free electrochemical cross-coupling
hydrogen evolution reaction of glycine amides with diarylphosphine oxides has been …
hydrogen evolution reaction of glycine amides with diarylphosphine oxides has been …
Cyclization of azobenzenes via electrochemical oxidation induced benzylic radical generation
A Li, X Li, F Ma, H Gao, H Li - Organic Letters, 2023 - ACS Publications
An electrochemical oxidation-induced cyclization of ortho-alkyl-substituted azobenzenes
has been developed. The direct electrochemical benzylic C–H functionalization with respect …
has been developed. The direct electrochemical benzylic C–H functionalization with respect …