mRNA-based therapeutics: powerful and versatile tools to combat diseases

S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

COVID-19 vaccines in patients with cancer: immunogenicity, efficacy and safety

A Fendler, EGE de Vries… - Nature Reviews …, 2022 - nature.com
Patients with cancer have a higher risk of severe coronavirus disease (COVID-19) and
associated mortality than the general population. Owing to this increased risk, patients with …

Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study

A Fendler, STC Shepherd, L Au, KA Wilkinson, M Wu… - Nature cancer, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) antiviral response in a pan-tumor immune
monitoring (CAPTURE)(NCT03226886) is a prospective cohort study of COVID-19 immunity …

Immunological and clinical efficacy of COVID-19 vaccines in immunocompromised populations: a systematic review

S Galmiche, LBL Nguyen, E Tartour… - Clinical Microbiology …, 2022 - Elsevier
Background Available data show that COVID-19 vaccines may be less effective in
immunocompromised populations, who are at increased risk of severe COVID-19 …

mRNA-1273 COVID-19 vaccination in patients receiving chemotherapy, immunotherapy, or chemoimmunotherapy for solid tumours: a prospective, multicentre, non …

SF Oosting, AAM van der Veldt… - The Lancet …, 2021 - thelancet.com
Background Patients with cancer have an increased risk of complications from SARS-CoV-2
infection. Vaccination to prevent COVID-19 is recommended, but data on the …

Highly variable SARS-CoV-2 spike antibody responses to two doses of COVID-19 RNA vaccination in patients with multiple myeloma

O Van Oekelen, CR Gleason, S Agte, K Srivastava… - Cancer cell, 2021 - cell.com
COVID-19 mRNA vaccines are highly efficacious in preventing COVID-19 morbidity and
mortality in phase 3 clinical studies as well as in real-world settings. Emerging evidence …

[HTML][HTML] Immunogenicity and risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection after coronavirus disease 2019 (COVID-19) vaccination …

A Becerril-Gaitan, BF Vaca-Cartagena… - European journal of …, 2022 - Elsevier
Background Patients with cancer are considered a priority group for Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vaccination given their high risk of …

Risk and outcome of breakthrough COVID-19 infections in vaccinated patients with cancer: real-world evidence from the national COVID cohort collaborative

Q Song, B Bates, YR Shao, FC Hsu, F Liu… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE To provide real-world evidence on risks and outcomes of breakthrough COVID-
19 infections in vaccinated patients with cancer using the largest national cohort of COVID …

Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer

LC Shapiro, A Thakkar, ST Campbell, SK Forest… - Cancer Cell, 2022 - cell.com
We and others have shown the significant impact of COVID-19 infection among patients with
a cancer diagnosis, with increased morbidity and mortality with advanced age, co …

Immune responses against SARS-CoV-2 variants after two and three doses of vaccine in B-cell malignancies: UK PROSECO study

SH Lim, B Stuart, D Joseph-Pietras, M Johnson… - Nature cancer, 2022 - nature.com
Patients with hematological malignancies are at increased risk of severe COVID-19
outcomes due to compromised immune responses, but the insights of these studies have …