The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …

An estimated 50% of depressed patients are inadequately treated by available interventions.
Even with an eventual recovery, many patients require a trial and error approach, as there …

Depressive disorders (DDs) are one of the most widespread forms of psychiatric pathology.
According to the World Health Organization, about 350 million people in the world are …

Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …

Amino acid transporters (AATs) are membrane-bound transport proteins that mediate
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …

Research into the causes of psychopathology has largely focused on two broad etiologic
factors: genetic vulnerability and environmental stressors. An important role for …

Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …

Major depression is the commonest psychiatric disorder and in the US has the greatest
impact of all biomedical diseases on disability. Here we review evidence of the genetic …

Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have
met with limited success. We sought to increase statistical power to detect disease loci by …

The prevalence of metabolic diseases is growing worldwide. Accumulating evidence
suggests that solute carrier (SLC) transporters contribute to the etiology of various metabolic …