The lung is a highly specialized organ that facilitates uptake of oxygen and release of
carbon dioxide. Due to its unique structure providing enormous surface area to outside …

The epidermal growth factor receptor (EGFR) has emerged as an attractive therapeutic
target for patients with non–small-cell lung cancer (NSCLC). However, despite its almost …

Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC)
and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene …

Background: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor
receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these …

Background A clinical trial that compared erlotinib with a placebo for non–small-cell lung
cancer demonstrated a survival benefit for erlotinib. We used tumor-biopsy samples from …

Caspases play a central role in apoptosis, a well-studied pathway of programmed cell death.
Other programs of death potentially involving necrosis and autophagy may exist, but their …

Purpose: Epidermal growth factor receptor (EGFR) mutations related to gefitinib
responsiveness in non–small cell lung cancer have been found recently. Detection of EGFR …

Purpose: Gefitinib and erlotinib can penetrate into the central nervous system (CNS) and
elicit responses in patients with brain metastases (BM) from non–small cell lung cancer …

Abstract Learning Objectives After completing this course, the reader will be able to:
Describe the clinical and pathological characteristics of the cutaneous rash secondary to …

Early clinical studies of tyrosine kinase inhibitors (TKIs) that target the EGFR in patients with
advanced non-small-cell lung cancer (NSCLC) showed that some patients experienced …