Purines perform many important functions in the cell, being the formation of the monomeric
precursors of nucleic acids DNA and RNA the most relevant one. Purines which also …

The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

The tumor microenvironment is characterized by of high levels of extracellular nucleotides
that are metabolized through the dynamic and sequential action of cell surface enzymes …

The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …

The growing evidence of the involvement of purine compounds in signaling, of nucleotide
imbalance in tumorigenesis, the discovery of purinosome and its regulation, cast new light …

Adenosine is an endogenous purine nucleoside that acts in all living systems as a
homeostatic network regulator through many pathways, which are adenosine receptor (AR) …

Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly,
plays a complex role in multiple physiological and pathophysiological processes by …

Interest in adenosine deaminase (ADA) in the context of medicine has mainly focused on its
enzymatic activity. This is justified by the importance of the reaction catalyzed by ADA not …

AG protein-coupled receptor heteromer that fulfills the established criteria for its existence in
vivo is the complex between adenosine A2A (A2AR) and dopamine D2 (D2R) receptors …

Adenosine receptors are a family of GPCRs containing four subtypes (A1, A2A, A2B and A3
receptors), all of which bind the ubiquitous nucleoside adenosine. These receptors play an …