Simple Summary Growth factors are hormone-like molecules able to promote division and
migration of normal cells, but cancer captured the underlying mechanisms to unleash tumor …

Cancer is a heavy burden for humans across the world with high morbidity and mortality.
Transcription factors including sex determining region Y (SRY)-related high-mobility group …

The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical
role in controlling cell specification, cell–cell interaction and tissue patterning during …

The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a
consequence of improper control, aberrant HH signaling results in tumorigenesis and …

Prostate cancer (PCa) is a common and fatal type of cancer in men. Metastatic PCa (mPCa)
is a major factor contributing to its lethality, although the mechanisms remain poorly …

SOX2 (Sex-determining region Y (SRY)-Box2) has important functions during embryonic
development and is involved in cancer stem cell (CSC) maintenance, in which it impairs cell …

Non-small-cell lung cancer is often diagnosed at the metastatic stage, with median survival
of just 1 year. The identification of driver mutations in the epidermal growth factor receptor …

Melanoma is one of the most aggressive types of human cancer, characterized by enhanced
heterogeneity and resistance to conventional therapy at advanced stages. We and others …

Chemokine networks regulate a variety of cellular, physiological, and immune processes.
These normal functions can become appropriated by cancer cells to facilitate a more …

Basal cell carcinomas (BCCs) and a subset of medulloblastomas are characterized by loss-
of-function mutations in the tumor suppressor gene, PTCH1. PTCH1 normally functions by …