The birth of 'Dolly', the first mammal cloned from an adult donor cell, has sparked a flurry of
research activities to improve cloning technology and to understand the underlying …

Ovarian follicular growth and maturation and its control throughout pregnancy have not been
described fully in sheep. Experiment 1 characterized the size and maturation (steroid …

Background: In an era where around one in four children in the United Kingdom, the United
States, and Australia are overweight or obese, the development of obesity in early life needs …

2 型糖尿病(T2DM) 是由遗传因素和环境因素共同作用而形成的多基因遗传性疾病,
是一种复杂的异质性的糖代谢性疾病, 主要包括高血糖反应, 胰岛功能受损和(或) …

摘要背景: 昼夜节律紊乱可导致各种健康问题. 当前这项研究在日本人群中评估了核心昼夜节律
基因上的昼夜节律时钟调节器(core circadian gene clock circadian regulator, CLOCK) …

Compromised pregnancies such as those associated with gestational diabetes mellitus,
intrauterine growth retardation, preeclampsia, maternal undernutrition, and maternal stress …

The development of a normal ovary during foetal life is essential for the production and
ovulation of a high-quality oocyte in adult life. Early in embryogenesis, the primordial germ …

Conventional (whole body) CYP2E1 knockout mice displayed protection against high-fat
diet-induced weight gain, obesity, and hyperlipidemia with increased energy expenditure …

Background Famine provides quasi-experimental conditions for testing the hypothesis of
“programming” health effects by poor nutrition in early life. It remains uncertain whether early …

The 'fetal origin hypothesis' suggests that metabolic diseases are directly related to poor
nutritional status in early life. Thus, a high birth weight (HBW) may pose a lower risk than …