Putting p53 in context
ER Kastenhuber, SW Lowe - Cell, 2017 - cell.com
TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by
a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative …
a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative …
Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation
SY Lee, EK Jeong, MK Ju, HM Jeon, MY Kim, CH Kim… - Molecular cancer, 2017 - Springer
Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …
Cancer risk across mammals
Cancer is a ubiquitous disease of metazoans, predicted to disproportionately affect larger,
long-lived organisms owing to their greater number of cell divisions, and thus increased …
long-lived organisms owing to their greater number of cell divisions, and thus increased …
A comparative genomics multitool for scientific discovery and conservation
Nature, 2020 - nature.com
Abstract The Zoonomia Project is investigating the genomics of shared and specialized traits
in eutherian mammals. Here we provide genome assemblies for 131 species, of which all …
in eutherian mammals. Here we provide genome assemblies for 131 species, of which all …
Role of telomeres and telomerase in aging and cancer
JW Shay - Cancer discovery, 2016 - AACR
Telomeres progressively shorten throughout life. A hallmark of advanced malignancies is
the ability for continuous cell divisions that almost universally correlates with the stabilization …
the ability for continuous cell divisions that almost universally correlates with the stabilization …
Pancreatic cancer biology and genetics from an evolutionary perspective
A Makohon-Moore, CA Iacobuzio-Donahue - Nature Reviews Cancer, 2016 - nature.com
Cancer is an evolutionary disease, containing the hallmarks of an asexually reproducing
unicellular organism subject to evolutionary paradigms. Pancreatic ductal adenocarcinoma …
unicellular organism subject to evolutionary paradigms. Pancreatic ductal adenocarcinoma …
Mechanisms of cancer resistance in long-lived mammals
A Seluanov, VN Gladyshev, J Vijg… - Nature Reviews Cancer, 2018 - nature.com
Cancer researchers have traditionally used the mouse and the rat as staple model
organisms. These animals are very short-lived, reproduce rapidly and are highly prone to …
organisms. These animals are very short-lived, reproduce rapidly and are highly prone to …
Gain-of-function mutant p53: all the roads lead to tumorigenesis
Y Stein, V Rotter, R Aloni-Grinstein - International journal of molecular …, 2019 - mdpi.com
The p53 protein is mutated in about 50% of human cancers. Aside from losing the tumor-
suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent …
suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent …
TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants
A major constraint on the evolution of large body sizes in animals is an increased risk of
developing cancer. There is no correlation, however, between body size and cancer risk …
developing cancer. There is no correlation, however, between body size and cancer risk …
Genomic instability in cancer: teetering on the limit of tolerance
Cancer genomic instability contributes to the phenomenon of intratumoral genetic
heterogeneity, provides the genetic diversity required for natural selection, and enables the …
heterogeneity, provides the genetic diversity required for natural selection, and enables the …