Obesity is a growing epidemic that contributes to several brain disorders including
Alzheimer's, Parkinson's, and Huntington's diseases. Obesity could promote these diseases …

Enormous strides in understanding aging have come from the discovery that mutations in
single genes can extend healthy life-span in laboratory model organisms such as the yeast …

Context: Measurement of IGF-I is a cornerstone in diagnosis and monitoring of GH-related
diseases, but considerable discrepancies exist between analytical methods. A recent …

Objective To describe demographic and hormonal characteristics, comorbidities (diabetes
mellitus and hypertension), therapeutic procedures and their effectiveness, as well as …

Objectives Previous studies suggested that vitamin D modulates circulating IGF1. We
investigated this effect in adults and its clinical relevance in the management of GH …

Centenarians' offspring represent a suitable model to study age-dependent variables (eg
IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was …

Context: A reduced activity of the GH/IGF-I axis in chronic heart failure (CHF) has been
described by several independent groups and is associated with poor clinical status and …

Purpose Patients with secondary adrenal insufficiency (SAI) have an increased morbidity
and an impaired health-related quality of life (HRQoL), which seems to primarily depend on …

Aim: Chronic iron overload resulting from frequent transfusions, poor compliance to efficient
chelation therapy and chronic liver disease is basically responsible for the most severe …

The molecular and cellular mechanisms, which coordinate the critical stages of brain
development to reach a normal structural organization with appropriate networks, are …