Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

Artificial neural networks (ANNs) have undergone a revolution, catalyzed by better
supervised learning algorithms. However, in stark contrast to young animals (including …

Here we report the generation of a multimodal cell census and atlas of the mammalian
primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network …

Dendritic and axonal morphology reflects the input and output of neurons and is a defining
feature of neuronal types,, yet our knowledge of its diversity remains limited. Here, to …

Prefrontal cortex (PFC) is the cognitive center that integrates and regulates global brain
activity. However, the whole-brain organization of PFC axon projections remains poorly …

The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in
perception, cognition, emotion, and learning. We profiled∼ 1.3 million cells covering the …

We used the 10x Genomics Visium platform to define the spatial topography of gene
expression in the six-layered human dorsolateral prefrontal cortex. We identified extensive …

During neurogenesis, mitotic progenitor cells lining the ventricles of the embryonic mouse
brain undergo their final rounds of cell division, giving rise to a wide spectrum of postmitotic …

Tau aggregation in neurofibrillary tangles (NFTs) is closely associated with
neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the …

The mammalian cortex is a laminar structure containing many areas and cell types that are
densely interconnected in complex ways, and for which generalizable principles of …