Systemic sclerosis (SSc) is a clinically heterogeneous disorder of the connective tissue
characterized by vascular alterations, immune/inflammatory manifestations, and organ …

Foxp3+ regulatory T (Treg) cells are a CD4 T cell subset with unique immune regulatory
function that are indispensable in immunity and tolerance. Their indisputable importance …

Systemic sclerosis (SSc) is a complex disease that affects the connective tissue, causing
fibrosis. SSc patients show altered immune cell composition and activation in the peripheral …

Vasculogenic mimicry (VM) describes the ability of highly aggressive tumor cells to develop
pseudovascular structures without the participation of endothelial cells. PARP1 is implicated …

Objective CD38 is a type II glycoprotein highly expressed on plasmablasts and on short-and
long-lived plasma cells, but weakly expressed by lymphoid, myeloid, and non-hematopoietic …

Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is rare, poorly understood,
with heterogeneous characteristics resulting in difficult diagnosis. We aimed to …

Systemic sclerosis (SSc) is a systemic disease characterized by autoimmune responses,
vasculopathy and tissue fibrosis. The pathogenic mechanisms involve a wide range of cells …

We previously reported that Smad anchor for receptor activation (SARA) plays a critical role
in maintaining epithelial cell phenotype. Here, we show that SARA suppressed …

Systemic rheumatic diseases, such as rheumatoid arthritis, systemic lupus erythematosus,
and systemic sclerosis, are chronic autoimmune diseases affecting multiple organs and …

Systemic sclerosis (SSc) is a chronic immune-mediated disease characterized by
microangiopathy, immune dysregulation, and progressive fibrosis of the skin and internal …