Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …

Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the MAPK
kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of …

Many cancer cells display enhanced glycolysis and suppressed mitochondrial metabolism.
This phenomenon, known as the Warburg effect, is critical for tumor development. However …

Glycosylation is crucial in cellular metabolism and survival. Of interest is the role of N-linked
and O-linked glycans in disease states. Robust analytical methods must be defined to …

Alzheimer's disease (AD) is the most common form of age-related dementia. Despite
decades of research, the etiology and pathogenesis of AD are not well understood. Brain …

The pentose phosphate pathway (PPP) plays a critical role in macromolecule biosynthesis
and maintaining cellular redox homoeostasis in rapidly proliferating cells. Upregulation of …

Abstract O-linked β-DN-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) onto
serine and threonine residues of proteins is an important post-translational modification …

This chapter presents an overview of the dynamic modification of serine or threonine
hydroxyl moieties on nuclear, mitochondrial, and cytoplasmic proteins by O-linked β-N …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by loss of
dopaminergic neurons and localized neuroinflammation occurring in the midbrain several …

In the 30 years, since the discovery of nucleocytoplasmic glycosylation, O-GlcNAc has been
implicated in regulating cellular processes as diverse as protein folding, localization …