[HTML][HTML] Patients with COVID-19: in the dark-NETs of neutrophils
SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs,
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it …
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it …
Management strategies and future directions for systemic lupus erythematosus in adults
L Durcan, T O'Dwyer, M Petri - The Lancet, 2019 - thelancet.com
Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the loss of
self-tolerance and formation of nuclear autoantigens and immune complexes resulting in …
self-tolerance and formation of nuclear autoantigens and immune complexes resulting in …
[HTML][HTML] Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus
Increased risk of premature cardiovascular disease (CVD) is well recognized in systemic
lupus erythematosus (SLE). Aberrant type I-Interferon (IFN)-neutrophil interactions contribute …
lupus erythematosus (SLE). Aberrant type I-Interferon (IFN)-neutrophil interactions contribute …
JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
DM Schwartz, Y Kanno, A Villarino, M Ward… - Nature reviews Drug …, 2017 - nature.com
The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …
[HTML][HTML] The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
F Seif, M Khoshmirsafa, H Aazami… - Cell communication and …, 2017 - Springer
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway
plays critical roles in orchestrating of immune system, especially cytokine receptors and they …
plays critical roles in orchestrating of immune system, especially cytokine receptors and they …
[HTML][HTML] JAK–STAT signaling as a target for inflammatory and autoimmune diseases: current and future prospects
The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling
pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases …
pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases …
Neutrophil extracellular traps (NETs) in autoimmune diseases: a comprehensive review
KH Lee, A Kronbichler, DDY Park, YM Park, H Moon… - Autoimmunity …, 2017 - Elsevier
Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the
membranes of activated neutrophils. NETs are found in a variety of conditions such as …
membranes of activated neutrophils. NETs are found in a variety of conditions such as …
JAK inhibitors for the treatment of autoimmune and inflammatory diseases
Y Jamilloux, T El Jammal, L Vuitton… - Autoimmunity …, 2019 - Elsevier
Cytokines play a central role in the pathophysiology of autoimmune and inflammatory
diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized …
diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized …
[HTML][HTML] JAK inhibitors and autoimmune rheumatic diseases
M Benucci, P Bernardini, C Coccia, R De Luca… - Autoimmunity …, 2023 - Elsevier
The four Janus kinase (JAK) proteins and the seven Signal Transducers of Activated
Transcription (STAT) mediate intracellular signal transduction downstream of cytokine …
Transcription (STAT) mediate intracellular signal transduction downstream of cytokine …
[HTML][HTML] Aberrant T cell signaling and subsets in systemic lupus erythematosus
T Katsuyama, GC Tsokos, VR Moulton - Frontiers in immunology, 2018 - frontiersin.org
Systemic lupus erythematosus (SLE) is a chronic multi-organ debilitating autoimmune
disease, which mainly afflicts women in the reproductive years. A complex interaction of …
disease, which mainly afflicts women in the reproductive years. A complex interaction of …