[HTML][HTML] Structure, function, and genetics of lipoprotein (a)

K Schmidt, A Noureen, F Kronenberg… - Journal of lipid …, 2016 - ASBMB
Lipoprotein (a)[Lp (a)] has attracted the interest of researchers and physicians due to its
intriguing properties, including an intragenic multiallelic copy number variation in the LPA …

[HTML][HTML] Lipoprotein (a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality

Emerging Risk Factors Collaboration - JAMA: the journal of the …, 2009 - ncbi.nlm.nih.gov
Lipoprotein(a) Concentration and the Risk of Coronary Heart Disease, Stroke, and Nonvascular
Mortality - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage …

Lipoprotein (a): resurrected by genetics

F Kronenberg, G Utermann - Journal of internal medicine, 2013 - Wiley Online Library
Plasma lipoprotein (a)[L p (a)] is a quantitative genetic trait with a very broad and skewed
distribution, which is largely controlled by genetic variants at the LPA locus on chromosome …

Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase

JB Cheng, MA Levine, NH Bell… - Proceedings of the …, 2004 - National Acad Sciences
The synthesis of bioactive vitamin D requires hydroxylation at the 1α and 25 positions by
cytochrome P450 enzymes in the kidney and liver, respectively. The mitochondrial enzyme …

[HTML][HTML] Human genetics and the causal role of lipoprotein (a) for various diseases

F Kronenberg - Cardiovascular drugs and therapy, 2016 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a highly atherogenic lipoprotein that is under strong
genetic control by the LPA gene locus. Genetic variants including a highly polymorphic copy …

Apolipoprotein (a) isoforms and the risk of vascular disease: systematic review of 40 studies involving 58,000 participants

S Erqou, A Thompson, E Di Angelantonio… - Journal of the American …, 2010 - jacc.org
Objectives: The purpose of this study was to assess the association of apolipoprotein
(a)(apo [a]) isoforms with cardiovascular disease risk. Background: Although circulating …

Lipoprotein (a) levels and risk of future coronary heart disease: large-scale prospective data

A Bennet, E Di Angelantonio, S Erqou… - Archives of internal …, 2008 - jamanetwork.com
Background Large-scale prospective data are needed to determine whether associations
between lipoprotein (a)(Lp [a]) and coronary heart disease (CHD) risk are independent of …

Race is a key variable in assigning lipoprotein (a) cutoff values for coronary heart disease risk assessment: the Multi-Ethnic Study of Atherosclerosis

W Guan, J Cao, BT Steffen, WS Post… - … , and vascular biology, 2015 - Am Heart Assoc
Objective—We aimed to examine associations of lipoprotein (a)(Lp (a)) concentrations with
coronary heart disease (CHD) and determine whether current Lp (a) clinical laboratory cut …

Lipoprotein (a) an elusive cardiovascular risk factor

L Berglund, R Ramakrishnan - Arteriosclerosis, thrombosis, and …, 2004 - Am Heart Assoc
Lipoprotein (a)[Lp (a)], is present only in humans, Old World nonhuman primates, and the
European hedgehog. Lp (a) has many properties in common with low-density lipoprotein …

[HTML][HTML] IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans

N Müller, DM Schulte, K Türk, S Freitag-Wolf… - Journal of lipid …, 2015 - ASBMB
Lipoprotein (a)[Lp (a)] is a highly atherogenic lipid particle. Although earlier reports
suggested that Lp (a) levels are mostly determined by genetic factors, several recent studies …