Background Pre-clinical models demonstrate that platelet activation is involved in the spread
of malignancy. Ongoing clinical trials are assessing whether aspirin, which inhibits platelet …

Oxylipins have garnered increasing attention because they were consistently shown to play
pathological and/or pharmacological roles in the development of multiple cancers. Oxylipins …

Acetylsalicylic acid or aspirin is the most commonly used drug in the world and is taken daily
by millions of people. There is increasing evidence that chronic administration of low-dose …

Colorectal cancer (CRC) is one of the most common forms of cancer worldwide and
treatment options for advanced CRC, which has a low 5-year survival rate, remain limited …

Urinary prostaglandin (PG) E metabolite (PGE‐M) and 11‐dehydro (d)‐thromboxane (TX)
B2 are biomarkers of cyclooxygenase‐dependent prostanoid synthesis. We investigated (1) …

Metabolic dysfunction-associated steatotic liver disease (MASLD) is not only related to
traditional cardiovascular risk factors like type 2 diabetes mellitus and obesity, but it is also …

The Journal of Pharmacology and Experimental Therapeutics (JPET) is one of the leading
journals serving the membership of the American Society for Pharmacology and …

Aim To conduct a systematic review and meta-analysis of all randomized controlled trials
(RCTs) that evaluated the efficacy of low-dose aspirin (LDA,≤ 160 mg/day) on preventing …

We performed a bidirectional 2-sample Mendelian randomization (MR) design to explore the
causal relation between telomere length (TL) and colorectal polyps. Genome-wide …

Cancer and cardiovascular diseases (CVD) share a number of risk factors. On the other
hand, cancer, including breast cancer according to the metaanalysis work by Galimzhanov …