Significance: Blood–brain barrier (BBB) disruption is a major pathological change after
intracerebral hemorrhage (ICH) and is both the cause and result of oxidative stress and of …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

Background Neuroinflammation is an important host defense response to secondary brain
injury after intracerebral hemorrhage (ICH). Triggering receptor expressed on myeloid cells …

Background Neuroinflammation is a crucial factor in the development of secondary brain
injury after intracerebral hemorrhage (ICH). Irisin is a newly identified myokine that confers …

Puerarin was shown to exert anti-oxidative and anti-ferroptosis effects in multiple diseases.
The goal of this study was to explore the neuroprotective effect of puerarin on early brain …

Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder
characterized by an abnormal accumulation of amyloid-β (Aβ) plaques, neuroinflammation …

Obesity is a multifactorial disease in which environmental conditions and several genes play
an important role in the development of this disease. Obesity is associated with …

Oxidative stress and neuroinflammation play essential roles in ischemic stroke‐induced
brain injury. Previous studies have reported that Ezetimibe (Eze) exerts antioxidative stress …

Mitochondria-mediated oxidative stress and apoptosis contribute greatly to early brain injury
(EBI) following subarachnoid hemorrhage (SAH). This study hypothesized that activation of …

The prognosis of intracerebral haemorrhage continues to be devastating despite much
research into this condition. A prominent feature of intracerebral haemorrhage is …