Emerging targets in type 2 diabetes and diabetic complications

S Demir, PP Nawroth, S Herzig… - Advanced …, 2021 - Wiley Online Library
Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …

The role of miRNAs in insulin resistance and diabetic macrovascular complications–A review

SSA Mageed, AS Doghish, A Ismail… - International Journal of …, 2023 - Elsevier
Diabetes is the most prevalent metabolic disturbance disease and has been regarded
globally as one of the principal causes of mortality. Diabetes is accompanied by several …

Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus

J Yong, JD Johnson, P Arvan, J Han… - Nature Reviews …, 2021 - nature.com
Diabetes mellitus is characterized by the failure of insulin-secreting pancreatic β-cells (or β-
cell death) due to either autoimmunity (type 1 diabetes mellitus) or failure to compensate for …

[HTML][HTML] Obesity and type 2 diabetes mellitus: Connections in epidemiology, pathogenesis, and treatments

R Ruze, T Liu, X Zou, J Song, Y Chen, R Xu… - Frontiers in …, 2023 - frontiersin.org
The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …

[PDF][PDF] Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes

NJ Hogrebe, M Ishahak, JR Millman - Cell Stem Cell, 2023 - cell.com
The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …

[HTML][HTML] Phytochemical analysis and evaluation of antimicrobial, antioxidant, and antidiabetic activities of essential oils from Moroccan medicinal plants: Mentha …

N El Hachlafi, N Benkhaira, SH Al-Mijalli… - Biomedicine & …, 2023 - Elsevier
Mentha suaveolens, Lavandula stoechas, and Ammi visnaga are widely used in Moroccan
folk medicine against several pathological disorders, including diabetes and infectious …

[HTML][HTML] Carbohydrate-based drugs launched during 2000− 2021

X Cao, X Du, H Jiao, Q An, R Chen, P Fang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Carbohydrates are fundamental molecules involved in nearly all aspects of lives, such as
being involved in formating the genetic and energy materials, supporting the structure of …

β− Arrestins: structure, function, physiology, and pharmacological perspectives

J Wess, AB Oteng, O Rivera-Gonzalez… - Pharmacological …, 2023 - ASPET
The two β-arrestins, β-arrestin-1 and-2 (systematic names: arrestin-2 and-3, respectively),
are multifunctional intracellular proteins that regulate the activity of a very large number of …

Effects of oral administration of polystyrene nanoplastics on plasma glucose metabolism in mice

X Fan, X Wei, H Hu, B Zhang, D Yang, H Du, R Zhu… - Chemosphere, 2022 - Elsevier
Microplastic (MP) and nanoplastic (NP) induce neurotoxicity, cytotoxicity, and reproductive
system toxicity in mammals. However, the impacts of NPs on the endocrine system are …

[HTML][HTML] Insulin-like growth factor 1 (IGF-1) signaling in glucose metabolism in colorectal cancer

A Kasprzak - International journal of molecular sciences, 2021 - mdpi.com
Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide,
characterized by unfavorable curative effect and poor prognosis. Epidemiological data re …