Emerging targets in type 2 diabetes and diabetic complications
S Demir, PP Nawroth, S Herzig… - Advanced …, 2021 - Wiley Online Library
Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …
The role of miRNAs in insulin resistance and diabetic macrovascular complications–A review
Diabetes is the most prevalent metabolic disturbance disease and has been regarded
globally as one of the principal causes of mortality. Diabetes is accompanied by several …
globally as one of the principal causes of mortality. Diabetes is accompanied by several …
Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus
Diabetes mellitus is characterized by the failure of insulin-secreting pancreatic β-cells (or β-
cell death) due to either autoimmunity (type 1 diabetes mellitus) or failure to compensate for …
cell death) due to either autoimmunity (type 1 diabetes mellitus) or failure to compensate for …
[HTML][HTML] Obesity and type 2 diabetes mellitus: Connections in epidemiology, pathogenesis, and treatments
R Ruze, T Liu, X Zou, J Song, Y Chen, R Xu… - Frontiers in …, 2023 - frontiersin.org
The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …
[PDF][PDF] Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
NJ Hogrebe, M Ishahak, JR Millman - Cell Stem Cell, 2023 - cell.com
The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
[HTML][HTML] Phytochemical analysis and evaluation of antimicrobial, antioxidant, and antidiabetic activities of essential oils from Moroccan medicinal plants: Mentha …
N El Hachlafi, N Benkhaira, SH Al-Mijalli… - Biomedicine & …, 2023 - Elsevier
Mentha suaveolens, Lavandula stoechas, and Ammi visnaga are widely used in Moroccan
folk medicine against several pathological disorders, including diabetes and infectious …
folk medicine against several pathological disorders, including diabetes and infectious …
[HTML][HTML] Carbohydrate-based drugs launched during 2000− 2021
X Cao, X Du, H Jiao, Q An, R Chen, P Fang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Carbohydrates are fundamental molecules involved in nearly all aspects of lives, such as
being involved in formating the genetic and energy materials, supporting the structure of …
being involved in formating the genetic and energy materials, supporting the structure of …
β− Arrestins: structure, function, physiology, and pharmacological perspectives
The two β-arrestins, β-arrestin-1 and-2 (systematic names: arrestin-2 and-3, respectively),
are multifunctional intracellular proteins that regulate the activity of a very large number of …
are multifunctional intracellular proteins that regulate the activity of a very large number of …
Effects of oral administration of polystyrene nanoplastics on plasma glucose metabolism in mice
X Fan, X Wei, H Hu, B Zhang, D Yang, H Du, R Zhu… - Chemosphere, 2022 - Elsevier
Microplastic (MP) and nanoplastic (NP) induce neurotoxicity, cytotoxicity, and reproductive
system toxicity in mammals. However, the impacts of NPs on the endocrine system are …
system toxicity in mammals. However, the impacts of NPs on the endocrine system are …
[HTML][HTML] Insulin-like growth factor 1 (IGF-1) signaling in glucose metabolism in colorectal cancer
A Kasprzak - International journal of molecular sciences, 2021 - mdpi.com
Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide,
characterized by unfavorable curative effect and poor prognosis. Epidemiological data re …
characterized by unfavorable curative effect and poor prognosis. Epidemiological data re …