Diabetic infectious micromilieu (DIM) leads to a critical failure rate of osseointegration by
virtue of two main peculiarities: high levels of topical glucose and inevitable infection. To …

Bacteria, viruses, protozoa, and fungi establish a complex ecosystem in the gut. Like other
microbiota, gut mycobiota plays an indispensable role in modulating intestinal physiology …

Human embryonic stem cell-derived β cells (SC-β cells) hold great promise for treatment of
diabetes, yet how to achieve functional maturation and protect them against metabolic …

The rising predominance of type 2 diabetes, combined with the poor medical effects seen
with commercially available anti-diabetic medications, has motivated the development of …

Background & Aims Interstitial cells of Cajal (ICCs) and pancreatic β cells require receptor
tyrosine kinase (KIT) to develop and function properly. Degeneration of ICCs is linked to …

Genome-wide association studies (GWASs) identified hundreds of signals associated with
type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have …

Diabetic infectious microenvironment (DIME) frequently leads to a critical failure of
osseointegration by virtue of its main peculiarities including typical hyperglycemia and …

Aims/hypothesis Pancreatic beta cell dedifferentiation, transdifferentiation into other islet
cells and apoptosis have been implicated in beta cell failure in type 2 diabetes, although the …

A high caloric intake, rich in saturated fats, greatly contributes to the development of obesity,
which is the leading risk factor for type 2 diabetes (T2D). A persistent caloric surplus …

Ferroptosis, a new type of cell death, is associated with pancreatic β cell damage. However,
the role of glucolipotoxicity in inducing β cell ferroptosis remains unclear. Metformin (Met) …