MCP-1: Function, regulation, and involvement in disease

S Singh, D Anshita, V Ravichandiran - International immunopharmacology, 2021 - Elsevier
Abstract MCP-1 (Monocyte chemoattractant protein-1), also known as Chemokine (CC-motif)
ligand 2 (CCL2), is from family of CC chemokines. It has a vital role in the process of …

Role of the CCL2‐CCR2 signalling axis in cancer: mechanisms and therapeutic targeting

M Xu, Y Wang, R Xia, Y Wei, X Wei - Cell proliferation, 2021 - Wiley Online Library
The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and
progression of various cancers. CCL2 can activate tumour cell growth and proliferation …

More than just attractive: how CCL2 influences myeloid cell behavior beyond chemotaxis

M Gschwandtner, R Derler, KS Midwood - Frontiers in immunology, 2019 - frontiersin.org
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is renowned for its ability to drive the
chemotaxis of myeloid and lymphoid cells. It orchestrates the migration of these cell types …

[HTML][HTML] Targeting the CCL2-CCR2 signaling axis in cancer metastasis

SY Lim, AE Yuzhalin, AN Gordon-Weeks, RJ Muschel - Oncotarget, 2016 - ncbi.nlm.nih.gov
The CCL2-CCR2 signaling axis has generated increasing interest in recent years due to its
association with the progression of cancer. Although first described as a chemotactic …

Interleukin-6, CXCL10 and infiltrating macrophages in COVID-19-related cytokine storm: not one for all but all for one!

F Coperchini, L Chiovato, M Rotondi - Frontiers in immunology, 2021 - frontiersin.org
SARS-COV-2 virus is responsible for the ongoing devastating pandemic. Since the early
phase of the pandemic, the “cytokine-storm” appeared a peculiar aspect of SARS-COV-2 …

The cytokine storm in COVID-19: Further advances in our understanding the role of specific chemokines involved

F Coperchini, L Chiovato, G Ricci, L Croce… - Cytokine & Growth …, 2021 - Elsevier
SARS-COV-2 infection represents the greatest pandemic of the world, counting daily
increasing number of subjects positive to the virus and, sadly, increasing number of deaths …

[HTML][HTML] Biomarkers in chronic kidney disease, from kidney function to kidney damage

S Lopez-Giacoman, M Madero - World journal of nephrology, 2015 - ncbi.nlm.nih.gov
Chronic kidney disease (CKD) typically evolves over many years, with a long latent period
when the disease is clinically silent and therefore diagnosis, evaluation and treatment is …

CCL2 shapes macrophage polarization by GM-CSF and M-CSF: identification of CCL2/CCR2-dependent gene expression profile

E Sierra-Filardi, C Nieto, Á Domínguez-Soto… - The Journal of …, 2014 - journals.aai.org
The CCL2 chemokine mediates monocyte egress from bone marrow and recruitment into
inflamed tissues through interaction with the CCR2 chemokine receptor, and its expression …

Monocyte chemoattractant protein-1 (MCP-1): an overview

SL Deshmane, S Kremlev, S Amini… - Journal of interferon & …, 2009 - liebertpub.com
Chemokines constitute a family of chemoattractant cytokines and are subdivided into four
families on the basis of the number and spacing of the conserved cysteine residues in the N …

Allergic rhinitis and its impact on asthma

J Bousquet, P Van Cauwenberge… - Journal of allergy and …, 2001 - jacionline.org
Allergic rhinitis is clinically defined as a symptomatic disorder of the nose induced by an IgE-
mediated inflammation after allergen exposure of the membranes lining the nose. Symptoms …