Copper metabolism in cell death and autophagy
Copper is an essential trace element in biological systems, maintaining the activity of
enzymes and the function of transcription factors. However, at high concentrations, copper …
enzymes and the function of transcription factors. However, at high concentrations, copper …
The bioinorganic chemistry of mammalian metallothioneins
The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …
speculations since the discovery of the protein over 60 years ago. This article guides …
[HTML][HTML] The multifaceted roles of copper in cancer: A trace metal element with dysregulated metabolism, but also a target or a bullet for therapy
Simple Summary Copper is an essential element for human life. However, its redox activity
can be detrimental for the cell that developed highly coordinated pathways to chelate and …
can be detrimental for the cell that developed highly coordinated pathways to chelate and …
[HTML][HTML] Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis
Endothelial cells adopt tissue-specific characteristics to instruct organ development and
regeneration,. This adaptability is lost in cultured adult endothelial cells, which do not …
regeneration,. This adaptability is lost in cultured adult endothelial cells, which do not …
[HTML][HTML] A proximal-to-distal survey of healthy adult human small intestine and colon epithelium by single-cell transcriptomics
J Burclaff, RJ Bliton, KA Breau, MT Ok… - Cellular and molecular …, 2022 - Elsevier
Background & Aims Single-cell transcriptomics offer unprecedented resolution of tissue
function at the cellular level, yet studies analyzing healthy adult human small intestine and …
function at the cellular level, yet studies analyzing healthy adult human small intestine and …
[HTML][HTML] Heavy metal induced stress on wheat: phytotoxicity and microbiological management
Among many soil problems, heavy metal accumulation is one of the major agronomic
challenges that has seriously threatened food safety. Due to these problems, soil …
challenges that has seriously threatened food safety. Due to these problems, soil …
[HTML][HTML] Copper in cancer: from pathogenesis to therapy
D Guan, L Zhao, X Shi, X Ma, Z Chen - Biomedicine & Pharmacotherapy, 2023 - Elsevier
One of the basic trace elements for the structure and metabolism of human tissue is copper.
However, as a heavy metal, excessive intake or abnormal accumulation of copper in the …
However, as a heavy metal, excessive intake or abnormal accumulation of copper in the …
[HTML][HTML] Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets
Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …
key observation is the disruption of cellular homeostasis, often coinciding with disease …
[HTML][HTML] Circulating tumor DNA as an emerging liquid biopsy biomarker for early diagnosis and therapeutic monitoring in hepatocellular carcinoma
X Wu, J Li, A Gassa, D Buchner, H Alakus… - … journal of biological …, 2020 - ncbi.nlm.nih.gov
As one of the most common malignant tumors worldwide, hepatocellular carcinoma (HCC) is
known for its poor prognosis due to diagnosis only in advanced stages. Nearly 50% of the …
known for its poor prognosis due to diagnosis only in advanced stages. Nearly 50% of the …
Ferroptosis in gastrointestinal cancer: from mechanisms to implications
Ferroptosis is a form of regulated cell death that is initiated by excessive lipid peroxidation
that results in plasma membrane damage and the release of damage-associated molecular …
that results in plasma membrane damage and the release of damage-associated molecular …